Immune response to <i>Haemophilus influenzae</i> type b conjugate vaccine in preterm infants

Tsuda, Kennosuke; Iwasaki, Shigeo; Horiguchi, Haruko; Mori, Masaaki; Nishimaki, Shigeru; Seki, Kazuhiko; Taguri, Masataka; Yokota, Shumpei; Ishiwada, Naruhiko

doi:10.1111/j.1442-200x.2011.03505.x

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…Consistent with the mostly anti-inflammatory response to innate immune stimulation in premature infants, impaired responses to vaccines given around birth have been noted (Baxter, 2010; D’Angio, 2007; Tsuda et al, 2011). However, TLR-mediated cytokine responses of preterm infants change over the first year of life.…”

Section: Early Lifesupporting

confidence: 53%

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

et al. 2012

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Summary Given the "inborn" nature of the innate immune system, it is surprising to find that innate immune function does in fact change with age. Similar patterns of distinct Toll-like receptor (TLR)-mediated immune responses come to light when one contrasts innate immune development at the beginning of life with that toward the end of life. Importantly, these developmental patterns of innate cytokine responses correlate with clinical patterns of susceptibility to disease: A heightened risk of suffering from excessive inflammation is often detected in prematurely born infants, disappears over the first few months of life, and reappears toward the end of life. In addition, risk periods for particular infections in early life reemerge in older adults. The near-mirror-image patterns that emerge in contrasts of early versus late innate immune ontogeny emphasize changes in host-environment interactions as the underlying molecular and teleologic drivers.

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Section: Early Lifesupporting

confidence: 53%

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

et al. 2012

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“…Table 1 provides clues on the short-term effects of glucocorticoid exposure on immunity. With few exceptions [112][113][114][115], fetal cord blood was employed to measure parameters such as cytokine levels, cell counts or leukocyte function, which we classified into innate or adaptive immunity (refer to Table 1 for references). Hampered by the considerable heterogeneity in immune parameters between individuals [116], differences in the selected readouts and methodologies employed, and the small size of these studies, the collective data are conflicting and inconclusive.…”

Section: Consequences Of Fetal Glucocorticoid Exposure On Postnatal Imentioning

confidence: 99%

“…However, antenatal corticosteroid therapy was also associated with increased responses to Haemophilus influenzae type b [112], underscoring the need for more investigation on the role of prenatal glucocorticoids on humoral immune responses.…”

Section: Mechanisms That May Underly Glucocorticoid Induced Programmimentioning

confidence: 99%

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity

et al. 2016

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Endogenous levels of glucocorticoids rise during pregnancy to warrant development and maturation of the fetal organs close to birth. However, during most of the gestation, the fetus is protected from excessive biologically active endogenous glucocorticoids by placental and fetal expression of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). Maternal stress, which may overwhelm placental 11β-HSD2 activity with high glucocorticoid levels, or administration of synthetic glucocorticoids to improve the survival chances of the premature newborn, are associated to postnatal increased risk for immune diseases. Fetal exposure to excessive glucocorticoids may underlie this altered postnatal immunity. Here, we revise the role that placental and fetal 11β-HSD2, fetal glucocorticoid exposure, and programming of the offspring's the hypothalamic-pituitary-adrenal (HPA) axis play on concerted steps in immune fetal development. We could identify gaps in knowledge about glucocorticoid-induced programming of immune diseases. Finally, based on current evidence about glucocorticoid and HPA axis-mediated immune regulation, we hypothesize on mechanisms that could drive the enhanced risk for atopies, infections, and type I diabetes in offspring that were prenatally exposed to glucocorticoids.

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“…Immunization of preterm infants from Poland and Spain with a 13-valent pneumococcal conjugate vaccine at the ages of 2, 3, 4 and 12 months led to lower but acceptable antibody levels (11). Based on the response to Haemophilus influenzae type b (Hib) vaccine, schedule modification (12) and need for boosters (13) were recommended in Japan and Poland, respectively. In Bangladesh, hepatitis B vaccine (Hep-B) generated protective, but, <100 mIU/ml anti-HBs titers in 26.4% Preterm infants (14).…”

Section: Introductionmentioning

confidence: 99%

Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age

et al. 2021

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Childhood vaccination plays critical role in protecting infants from several dreaded diseases. Of the global 15 million preterm (PT) infants with compromised immune system born annually, India contributes to >3.5 million. Generation of adequate vaccine-induced immune response needs to be ensured of their protection. Immune response of Indian PT (n = 113) and full-term (FT, n = 80) infants to pentavalent vaccine administered as per the national recommendation was studied. Antibody titers against component antigens of pentavalent vaccine, immune cells profiling (T and B cells, monocytes and dendritic cells) and plasma cytokines were determined pre- and post-vaccination. Additionally, cell-mediated recall immune responses to pentavalent antigens were evaluated after short time antigenic exposure to infant PBMCs. Irrespective of gestational age (GA), all the infants developed adequate antibody response against tetanus, diphtheria, and protective but lower antibody levels for Haemophilus influenzae type-b and hepatitis B in preterm infants. Lower (~74%) protective antibody response to pertussis was independent of gestational age. PT-infants exhibited lower frequencies of CD4 T cells/dendritic cells/monocytes, increased plasma IL-10 levels and lower proliferation of central and effector memory T cells than in term-infants. Proliferative central memory response of FT-infants without anti-pertussis antibodies suggests protection from subsequent infection. Responder/non-responder PT-infants lacked immunological memory and could be infected with Bordetella. For hepatitis B, the recall response was gestational age-dependent and antibody status-independent. Humoral/cellular immune responses of PT-infants were dependent on the type of the immunogen. Preterm infants born before 32 weeks of gestation may need an extra dose of pentavalent vaccine for long lived robust immune response.

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Immune response to Haemophilus influenzae type b conjugate vaccine in preterm infants

Abstract: There is a possibility that perinatal factors and the environment unique to preterm infants are related to their lower antibody positivity rates compared to full-term infants. It may therefore be preferable to modify the proposed immunization schedule.

Cited by 10 publications

References 23 publications

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity

Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age

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