Immune response to hepatitis B virus vaccine in celiac subjects at diagnosis

Filippelli, Martina; Garozzo, Maria Teresa; Capizzi, Antonino; Spina, Massimo; Manti, Sara; Tardino, Lucia; Salpietro, Carmelo; Leonardi, ﻿Salvatore

doi:10.4254/wjh.v8.i26.1105

Cited by 19 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, HLA antigens may influence the clinical course of hepatitis B and hepatitis D superinfections [ 42 ]. Nevertheless, Filippelli et al [ 35 ] in their prospective study reported no statistically significant difference regarding the comparison of the distribution of vaccine response between the different genotypes (DQ2/DQ2, DQ2/DQ8, and other HLA alleles).…”

Section: Vaccination Immunogenicitymentioning

confidence: 99%

“…In studies that compared a cohort of children with CD to a control group, a significant difference in the response to HBV vaccination was constantly found between the two groups [ 12 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] ( Table 1 ). Wanting to clarify if age was a risk factor, Filippelli et al [ 35 ], by comparing the percentage of responders and non-responders among three age groups (0–5.5 years, 5.5–9.5 years and 9.5–17 years), found no significant differences between the youngest and the oldest group. The data on adult patients also confirmed the high failure rate of HBV vaccination in CD subjects [ 38 , 39 , 40 ].…”

Section: Vaccination Immunogenicitymentioning

confidence: 99%

See 1 more Smart Citation

Vaccinations and Immune Response in Celiac Disease

2020

View full text Add to dashboard Cite

Immune response to vaccinations in celiac patients is of growing scientific interest. However, some aspects of the relationship between celiac disease (CD) and vaccines are still unclear. A comprehensive search of published literature using the PubMed database was carried out using the following key terms: “adaptive immunity”, “celiac disease”, “humoral immune response”, “immunization”, and “vaccination”. To date, there is no evidence showing any causative association between vaccines and CD development. Therefore, vaccinations may be administered according to the modalities and timing of the National Immunization Schedule for each country. The rotavirus vaccine is currently recommended for the general population, and according to some data, it appears to reduce the risk for the development of CD autoimmunity in the early years of life. Regarding the hepatitis B virus, a booster dose of the vaccine is often required due to the low or the lost immune response rate in CD. Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. Finally, pneumococcal vaccines may be administered in patients with advancing age at diagnosis and concomitant risk factors. Future clinical practice guidelines for vaccination and monitoring programs in celiac patients could be recommended.

show abstract

Section: Vaccination Immunogenicitymentioning

confidence: 99%

Section: Vaccination Immunogenicitymentioning

confidence: 99%

Vaccinations and Immune Response in Celiac Disease

2020

View full text Add to dashboard Cite

show abstract

“…In particular, the HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies[ 8 , 9 ] and some HLA phenotypes have been associated with a less effective immunological response[ 10 ]. The available literature indicates that the immunological response to vaccines in children with CD does not differ markedly from that of general population and antibodies titres are high enough to provide long-term protection, except for hepatitis B virus (HBV)[ 11 - 24 ]. Although the mechanism for HBV vaccination failure in subjects with CD is unknown, a few hypotheses have been made.…”

Section: Introductionmentioning

confidence: 99%

Immune response to vaccines in children with celiac disease

Anania

Olivero

Spagnolo

et al. 2017

WJG

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most potent intervention for infectious disease prevention. Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. The available literature indicates that the immunological response to vaccines in CD children does not differ markedly from that of general population and antibody titres are high enough to provide long-term protection, except for hepatitis B virus vaccine. In this article, we review and discuss the scarce literature in this field in order to provide clinical practice guidelines to achieve the most efficient monitoring of the response to vaccines in pediatric CD patients.

show abstract

“…Therefore, the reduction of immune response function is the main reason of continuous replication of HBV in the body and the increasing viral load ( 4 ). Peripheral blood mononuclear cells (PBMC) play an important role in the process of antiviral immune response, and excessive apoptosis of PBMC after viral infection leads to the reduction of the bodys antiviral immune response function and an increase of virus load ( 5 , 6 ). However, the apoptotic mechanism of PBMC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Expression of PBMC apoptosis-related factors in patients with chronic hepatitis B and their relationships with clinical prognosis

Guo

Liang

2017

Exp Ther Med

View full text Add to dashboard Cite

The present study was conducted to investigate the expression of apoptosis-related factors in peripheral blood mononuclear cells (PBMC) of patients with chronic hepatitis B and their correlation to clinical prognosis. Sixty-two patients that were diagnosed with chronic hepatitis B were admitted to Xuzhou Hospital from March 2015 to February 2016 and were enrolled as the observation group, while 60 healthy subjects who were examined in the health examination center were selected as the control group. The PBMC of patients were collected, and mRNA expression levels of the apoptotic molecules (FAS, CASP3, CASP8 and CASP9) were measured using real-time fluorescence quantitative PCR. The protein expression levels of apoptosis-related genes in the plasma were detected using enzyme-linked immunosorbent assay (ELISA) and the serum HBV-DNA was quantitatively measured using real-time fluorescence quantitative PCR. The mRNA and protein expression levels of FAS, CASP3, CASP8 and CASP9 in the observation group were significantly higher than those in the control group (P<0.05). The positive rate and log value of the copy amount of HBV DNA in the observation group were significantly higher than those in the control group (P<0.05). The Pearson correlation coefficient analysis showed that FAS, CASP3, CASP8 and CASP9 were positively correlated with HBV DNA (P<0.05). The mRNA expression levels of FAS, CASP3, CASP8 and CASP9 in patients with negative HBV-DNA were significantly lower than those with positive HBV-DNA (P<0.05). Apoptosis of PBMCs play an important role in the occurrence and development of chronic hepatitis B, and is closely correlated to the level of serum virus replication and prognosis.

show abstract

Immune response to hepatitis B virus vaccine in celiac subjects at diagnosis

Abstract: This prospective study confirmed the lower percentage of response to HBV vaccine in celiac subjects. However, the underlying mechanism remains unclear and further studies are needed.

Cited by 19 publications

References 20 publications

Vaccinations and Immune Response in Celiac Disease

Vaccinations and Immune Response in Celiac Disease

Immune response to vaccines in children with celiac disease

Expression of PBMC apoptosis-related factors in patients with chronic hepatitis B and their relationships with clinical prognosis

Contact Info

Product

Resources

About