Immune Response to Helicobacter pylori

Mahdi, Batool Mutar

doi:10.5772/57480

Cited by 2 publications

(8 citation statements)

References 79 publications

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“…After the delivery of CagA into the cytosol of gastric epithelial cells, it becomes tyrosinephosphorylated and imitates a host cell protein in coupling and activation of various signaling factors. 27 This oncoprotein remains the only recognized mechanism that is translocated by the T4SS of H. pylori into gastric epithelial cells where it causes to the activation of the host cell kinases and consequently activates numerous signal transduction pathways. 27 Previously published researches disclosed that the protective effect of double-antigen vaccines is more specific than a single-component vaccine.…”

Section: Resultsmentioning

confidence: 99%

“…27 This oncoprotein remains the only recognized mechanism that is translocated by the T4SS of H. pylori into gastric epithelial cells where it causes to the activation of the host cell kinases and consequently activates numerous signal transduction pathways. 27 Previously published researches disclosed that the protective effect of double-antigen vaccines is more specific than a single-component vaccine. 25,28,29 Overall, RLC formulation can serve as a promising candidate for the fight against the H. pylori infection and possibly provide a prophylactic tool to reduce the progressive growth of H. pylori-associated gastric cancers.…”

Section: Resultsmentioning

confidence: 99%

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Helicobacter pylori Recombinant CagA Regulates Th1/Th2 Balance in a BALB/c Murine Model

et al. 2020

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Purpose: Helicobacter pylori is recognized as one of the prevalent causes of human gastricinfection. In the present study, the role of mixed immunization with H. pylori lipopolysaccharide(LPS) and recombinant cytotoxin-associated gene A (rCagA) as a stimulator of host immuneresponses was determined. Methods: BALB/c mice were immunized with different formulations by the systemic administrationat 14-day intervals. The effects of the formulations plus CpG adjuvants were assessed before andpost-immunization in separated studies. Moreover, the expression of Th1/Th2 cytokines wasquantified in sera of immunized mice using reverse transcription polymerase chain reaction (RTPCR)test and the protein levels confirmed with enzyme linked immunosorbent assay (ELISA).Finally, the specific antibody levels in sera were studied by ELISA and the tendency of cellularresponse was examined by IgG1/IgG2a ratio. Results: Data of Western blotting verified the presence of constructed protein. Analysisof lymphocyte proliferation showed that CpG-conjugated rCagA increases lymphocytesproliferation compared to the control group. Also, it was shown that formulations containing LPSand rCagA promote a Th1 response indicated by interferon-gamma expression and induced Th1/Th2 balance. Additionally, the specific IgG1, total IgG and IgG2a levels elevated in response toall treatments. Ultimately, the IgG2a/IgG1 ratio in the mice immunized with rCagA-containingformulations increased. Conclusion: These results indicated that rCagA protein carried with CpG adjuvant not onlymaintained its antigenicity throughout the experiment but also induced robust Th1-biasedimmune responses. Therefore, it holds promise for the production of an efficient vaccine againstH. pylori infection. <br />

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori Recombinant CagA Regulates Th1/Th2 Balance in a BALB/c Murine Model

et al. 2020

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“…42 Another kind of cell that penetrates the stomach mucosa is Th17, a subset of CD4+ T cells linked to inflammation and infections. 24…”

Section: Dendritic Cell (Dc)mentioning

confidence: 99%

“…26 41 In addition, H. pylori adheres to gastric mucosa cells and secretes various molecules that can alter the function of gastric epithelial cells. 24 Long-term active gastritis is linked to a higher CD4/ CD8 T-cell ratio in the stomach mucosa and a build-up of CD4+…”

Section: Dendritic Cell (Dc)mentioning

confidence: 99%

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Helicobacter pylori antigens as immunomodulators of immune system

Marzhoseyni,

Mousavi,

Ghotloo

2024

Helicobacter

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Helicobacter pylori (H. pylori) is one of the most prevalent human pathogens and the leading cause of chronic infection in almost half of the population in the world (~59%). The bacterium is a major leading cause of chronic gastritis, gastric and duodenal ulcers, and two type of malignancies, gastric adenocarcinoma and mucosa‐associated lymphoid tissue (MALT) lymphoma. Despite the immune responses mounted by the host, the bacteria are not cleared from the body resulting in a chronic infection accompanied by a chronic inflammation. Herein, a review of the literature discussing H. pylori antigens modulating the immune responses is presented. The mechanisms that are involved in the modulation of innate immune response, include modulation of recognition by pattern recognition receptors (PRRs) such as modulation of recognition by toll like receptors (TLR)4 and TLR5, modulation of phagocytic function, and modulation of phagocytic killing mediated by reactive oxygen species (ROS) and nitric oxide (NO). On the other hands, H. pylori modulates acquired immune response by the induction of tolerogenic dendritic cells (DCs), modulation of apoptosis, induction of regulatory T cells, modulation of T helper (Th)1 response, and modulation of Th17 response.

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Immune Response to Helicobacter pylori

Cited by 2 publications

References 79 publications

Helicobacter pylori Recombinant CagA Regulates Th1/Th2 Balance in a BALB/c Murine Model

Helicobacter pylori Recombinant CagA Regulates Th1/Th2 Balance in a BALB/c Murine Model

Helicobacter pylori antigens as immunomodulators of immune system

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