Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells

Croix, Denise A.; Samples, N.K.; VandeBerg, John L.; Stone, W. H.

doi:10.1016/0145-305x(89)90019-0

Cited by 30 publications

(8 citation statements)

References 9 publications

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“…One of the prominent differences between marsupials and eutherians is the prolonged primary immune response of marsupials. IgG levels have been reported as lasting as long as 37 weeks in the Brazilian opossum (Monodelphis domestica) (Croix et al 1989), as long as 26 weeks in the quokka (Setonix brachyurus) (Yadav 1971) and at least 15 weeks in this study. The nature of their secondary response remains unclear yet it appears to be again different to that of eutherians.…”

Section: Discussionsupporting

confidence: 56%

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High levels of variability in immune response using antigens from two reproductive proteins in brushtail possums

et al. 2005

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Immune-based fertility control is being considered as an effective long-term approach for controlling the pest brushtail possum (Trichosurus vulpecula) population in New Zealand. This relies heavily on the immune response of each immunised possum. A strong and lasting immune response in the majority of individuals in a population is essential. In this study, possums and the model macropod species, the tammar wallaby (Macropus eugenii) were immunised with either a luteinising hormone or androgen receptor synthetic peptide coupled to the carrier molecule KLH (keyhole limpet haemocyanin). The antibody response of wallabies to the antigens was relatively uniform. In contrast, the possum immunoglobulin response to both synthetic peptides and KLH was variable. The apparent high level of variation in the immune response of possums raises questions about the feasibility of using these two antigens to control possum numbers in New Zealand.

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Section: Discussionsupporting

confidence: 56%

“…The nature of their secondary response remains unclear yet it appears to be again different to that of eutherians. A typical eutherian immunisation regime does not appear to result in a true secondary response in marsupials (Croix et al 1989;Shearer et al 1995). These regimes have administered boosters prior to the immune response peaking.…”

Section: Discussionmentioning

confidence: 99%

High levels of variability in immune response using antigens from two reproductive proteins in brushtail possums

et al. 2005

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“…effective antibody response, and following a second immunization at 28 days, the antibody levels were boosted. When these antibody levels are compared with that of another marsupial (the gray short-tailed opossum, Monodelphis domestica), the antibody response by the Tasmanian devil appears far superior as the antibody titers with the Monodelphis peaked at around 500 (Croix et al, 1989), whereas the antibody levels produced by the devil reached a maximum level of around 50,000, i.e., 100 times more effective.…”

Section: Discussionmentioning

confidence: 94%

The Immune Response of the Tasmanian Devil (Sarcophilus harrisii) and Devil Facial Tumour Disease

et al. 2007

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One of the most remarkable aspects of Devil Facial Tumour Disease (DFTD) is its infectious nature, and for successful transmission it must avoid detection by the devil's immune system. For this to occur, the devil either is severely immunosuppressed or factors produced by the tumor contribute to its avoidance of immune detection. An analysis of the devil's immune system revealed the presence of normal-looking lymphoid organs and lymphoid cells. At a functional level the lymphocytes proliferated in response to mitogen stimulation. Subcutaneous injection of a cellular antigen produced a strong antibody response, providing compelling evidence that the devil has a competent immune system. Tumor cell analysis demonstrated that the tumor expresses the genes of the major histocompatibility complex; however, there was a limited diversity. Therefore, the most likely explanation for devil-to-devil transmission of DFTD is that the tumor is not recognized by the devil as ''non-self'' because of the limited genetic diversity. With its consistent morphology and relatively stable genome, this tumor would provide a reasonable target for a vaccine approach, provided the immune system can be coaxed into recognizing the tumor as ''non-self.''

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“…The dermal cellular immune response to S. scabiei infection has been examined in humans and animals including rabbits, dogs, foxes, chamois, and pigs (Sheahan, 1975;Ackerman, 1985;Van Neste, 1986;Morsy and Gaafar, 1989;Arlian et al, 1994Arlian et al, , 1996aArlian et al, , 1997Arlian, 1996;Little et al, 1998;Rode et al, 1998). Whilst marsupials have an immune system similar to that of eutherian mammals (Croix et al, 1989) differences have been identified such as slower antibody responses in some metatherians including wombats (Johnson et al, 1989;Wilkinson et al, 1992;Skerratt et al, 1997), suggesting that differences may exist in the immune response of wombats to S. scabiei that affect its ability to regulate the abundance of mites. In this study, conventional staining methods as well as immunohistochemistry using antibodies raised against conserved antigens were used to identify cell types in the dermis of common wombats infected with S. scabiei.…”

Section: Introductionmentioning

confidence: 99%

Cellular Response in the Dermis of Common Wombats (Vombatus Ursinus) Infected With Sarcoptes Scabiei Var. Wombati

Skerratt

2003

Journal of Wildlife Diseases

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The cellular response in the dermis of common wombats (Vombatus ursinus) with sarcoptic mange exhibited some typical aspects of an immune response to Sarcoptes scabiei. There was an induction phase for wombats experimentally infected with S. scabiei represented by absence of a dermal inflammatory infiltrate for at least 12 days after infection. T lymphocytes, plasma cells, mast cells, and neutrophils then entered the dermis, consistent with a type IV (delayed) hypersensitivity response. In free-living wombats with severe parakeratotic sarcoptic mange eosinophils were also present in the dermis suggesting that a type I (immediate) hypersensitivity response may develop after a type IV hypersensitivity response. Absence of plasma cells and B lymphocytes in free-living wombats with severe parakeratotic sarcoptic mange compared with their presence in wombats experimentally infected with S. scabiei suggested that some immune tolerance may develop with severe infections. A large proportion of cells in the dermal response were not identified but were possibly cells of connective tissue. The thickness of the epidermis increased within 4 days in response to S. scabiei infection. Some antibodies raised against human leucocyte antigens CD3, CD5, HLA-DP, DQ, DR, and CD79b cross-reacted with leucocyte antigens of common wombats and were used to identify cell types in inflammatory infiltrates using immunohistochemistry.

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Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells

Cited by 30 publications

References 9 publications

High levels of variability in immune response using antigens from two reproductive proteins in brushtail possums

High levels of variability in immune response using antigens from two reproductive proteins in brushtail possums

The Immune Response of the Tasmanian Devil (Sarcophilus harrisii) and Devil Facial Tumour Disease

Cellular Response in the Dermis of Common Wombats (Vombatus Ursinus) Infected With Sarcoptes Scabiei Var. Wombati

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