Immune response in pigs treated with therapeutic doses of enrofloxacin at the time of vaccination against Aujeszky's disease

Pomorska‐Mól, Małgorzata; Czyżewska‐Dors, Ewelina; Kwit, Krzysztof; Rachubik, J.; Lipowski, A.; Pejsak, Z.

doi:10.1016/j.rvsc.2015.04.003

Cited by 12 publications

(16 citation statements)

References 22 publications

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“…It has been shown that each of these antibiotics: tilmicosin, florfenicol and enrofloxacin suppresses the postvaccinal humoral immune response in chickens (Khalifeh and others 2009). The same findings were noted for enrofloxacin in pigs (Pomorska‐Mol and others 2015a). In contrast, in pigs vaccinated with an attenuated vaccine, doxycycline (DOXY) modulated only cell‐mediated response (Pomorska‐Mol and others 2014).…”

supporting

confidence: 82%

“…The mechanism of interaction between antibiotics and immune response was not clarified. The effect of antibiotics on cytokine secretion may be a possible explanation (Morikawa and others 1996, Suzaki and others 1999, Morikawa and others 2002, Williams and others 2005, Pomorska-Mol and others 2015a). Cytokines are the most influential factors that modulate the immune response.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is not an uncommon practice to vaccinate the pigs during antibiotic therapy. Antibiotic therapy seems to be underestimated when applying vaccination programmes in the field, even if it has been shown that antibiotics may have an effect on the host immune system (Borowski and others 1985, Pulverer 1992, Kuzin and others 2001, Khalifeh and others 2009, Uchiyama and others 2014, Pomorska‐Mol and others 2015a). Taking into account the previous reports, it is important to know if antibiotics commonly used in pigs may influence the postvaccinal immune response.…”

Section: Discussionmentioning

confidence: 99%

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Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

et al. 2016

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It addition to their antimicrobial properties, antibiotics can influence the host immune system (modulation of cytokine secretion, antibody production and T-cell proliferation). In the present study, the authors studied the effects of therapeutic doses of amoxicillin (AMX), ceftiofur (CEF), doxycycline (DOXY), tiamulin (TIAM) and tulathromycin (TUL) on the postvaccinal immune response after pigs had been vaccinated against erysipelas. Because humoral immunity is considered as the most important in the protection against swine erysipelas, the present study focused on the interactions between antibiotics and postvaccinal humoral immunity. One hundred and five, eight-week-old pigs of both sexes were used. Specific antibodies to the Erysipelothrix rhusiopathiae antigen were determined using a commercial ELISA test. In pigs treated with DOXY or CEF or TIAM, a significant reduction in the number of positive pigs was observed four and six weeks after the second dose of vaccine, compared with the remaining vaccinated groups. In pigs treated with CEF, the ELISA score was significantly lower than in non-treated vaccinated pigs. While in vaccinated pigs treated with AMX or TUL, the ELISA score was significantly higher than in pigs treated with the remaining antibiotics and than in non-treated vaccinated controls. The results of the present study indicate that vaccination of pigs against erysipelas in the presence of antibiotics may result in a decrease (CEF, DOXY, TIAM) or enhancement (AMX, TUL) in the production of specific antibodies.

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supporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

et al. 2016

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“…Enrofloxacin has been widely used in pig breeding in China (Huang, Yu, You, & Zhang, ; Xu, Wang, Song, Fang, & Rao, ), but its adverse effects on the pig are limited to reports on its immune enhancement function (Pomorska‐Mól & Pejsak, ; Pomorska‐Mól et al., ; Schoevers et al., ). In this study, we found that the administration of EF caused an oxidative response in the pig liver cell, changed the CYP450 content and some CYP450 enzymatic activities, as well as altered the expression of some proteins in the pig liver microsome.…”

Section: Discussionmentioning

confidence: 99%

“…Lower concentrations of EF (<40 mg/kg bw) were shown to increase SOD activity in sturgeons, while a higher dose (>40 mg/kg bw) inhibited it (Li, Wang, Ma, & Lu, ). Enrofloxacin possesses immunomodulatory effects and may alter the immune response to vaccines at the therapeutic dose administered to pigs (Pomorska‐Mól & Pejsak, ; Pomorska‐Mól et al., ; Schoevers, Van Leengoed, Verheijden, & Niewold, ). The eco‐toxicological effect of the veterinary drug residues has also been paid attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

Effects of enrofloxacin on antioxidant system, microsomal enzymatic activity, and proteomics in porcine liver

Mou

Thunders

et al. 2018

Vet Pharm & Therapeutics

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Enrofloxacin (EF) is a widely used fluoroquinolone, usually regarded as a safe and effective treatment for bacterial infections. Adverse effects of EF have previously been demonstrated in some species, but so far there have been no studies looking specifically at the impact of EF on pigs. In this study, three different doses of EF (5, 25 and 125 mg kg bw ) were administrated to Bama pigs. The results showed that lipid peroxidation of pig liver tissue occurred with all EF doses. The 125 mg kg dose of EF induced catalase (CAT) and glutathione peroxidase (GSH-px) and increased CYP450 content in pig liver microsomes. The activity of microsomal NADPH-cytochrome C reductase (NCCR) was elevated at both the 25 and 125 mg kg doses of EF. Microsomal erythromycin N-demethylase (ERND) and aminopyrin N-demethylase (AND) were inhibited by high doses of EF, while aniline-4-hydroxylase (AH) was unaffected. None of the EF treatments affected superoxide dismutase (SOD) or cytochrome b5 content. Antioxidases and microsomal enzymes may work together to resist the adverse effects of EF. Proteomic analysis revealed increased protein expression of carboxylesterase (CES) and alpha-enolase (ENO1) in microsomes as a stress response to EF. These results provide new information about the adverse effect of fluoroquinolones and help guide their usage more effectively in the clinic or animal breeding.

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Aujeszky’s Disease

Dors

Mól

2017

Emerging and Re-Emerging Infectious Diseases of Livestock

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Immune response in pigs treated with therapeutic doses of enrofloxacin at the time of vaccination against Aujeszky's disease

Cited by 12 publications

References 22 publications

Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

Effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on pig humoral immune responses induced by erysipelas vaccination

Effects of enrofloxacin on antioxidant system, microsomal enzymatic activity, and proteomics in porcine liver

Aujeszky’s Disease

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