Immune Response Following Photodynamic Therapy For Bladder Cancer

Nseyo, Unyime O.; Whalen, Raymond K.; Duncan, Matthew R.; Berman, Brian; Lundahl, Scott L.

doi:10.1117/12.978005

Cited by 2 publications

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“…A comprehensive total of 1,688 articles were included in this research, covering the time period from 1989 to 2023. The first article related to PDT and immunity was published in 1989 ( Nseyo et al, 1989 ). As depicted in Figure 1 , the number of articles has shown a consistent upward trend since 1989.…”

Section: Resultsmentioning

confidence: 99%

Bibliometric analysis of photodynamic therapy and immune response from 1989–2023

Fan,

Tang,

Tang

et al. 2024

Front. Pharmacol.

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Objective: Photodynamic therapy (PDT) is a minimally invasive treatment approach for precancerous and cancerous lesions, known for its ability to activate the host immune response. This study conducted a bibliometric analysis to identify the research trends and hotspots related to the immune response in PDT.Methods: We analyzed articles and reviews published from 1989 to 2023, retrieved from the Web of Science database. Using Citespace and VOSviewer, we visualized the distribution patterns of these studies in time and space.Results: The analysis revealed a substantial increase in the number of publications on PDT-related immune response since 1989. A total of 1,688 articles from 1,701 institutions were included in this analysis. Among thei nstitutions, the Chinese Academy of Sciences demonstrated exceptional productivity and a willingness to collaborate with others. Additionally, 8,567 authors contributed to the field, with Mladen Korbelik, Michael R. Hamblin, and Wei R. Chen being the most prolific contributors. The current research focus revolves around novel strategies to enhance antitumor immunity in PDT, including PDT-based dendritic cell vaccines, combination therapies with immune checkpoint inhibitors (ICIs), and the use of nanoparticles for photosensitizer delivery. Furthermore, genes such as CD8A, TNF, CD4, IFNG, CD274, IL6, IL10, CALR, HMGB1, and CTLA4 have been evaluated in the context of PDT-related immunity.Conclusion: PDT not only achieves tumor ablation but also stimulates the immune response, bolstering antitumor immunity. This study highlights the emerging hotspots in PDT-related immune response research and provides valuable insights for future investigations aimed at further enhancing antitumor immunity.

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Section: Resultsmentioning

confidence: 99%

Bibliometric analysis of photodynamic therapy and immune response from 1989–2023

Fan,

Tang,

Tang

et al. 2024

Front. Pharmacol.

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Stress Protein Expression in Murine Tumor Cells Following Photodynamic Therapy With Benzoporphyrin Derivative

Curry

Levy

1993

Photochem & Photobiology

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Photodynamic therapy (PDT) has been proven as a method of tumor eradication and is currently being used clinically to treat a wide variety of malignancies. Although it is understood that the interaction of light and sensitizer results in the production of potentially damaging oxygen species, the mechanism by which tumors are destroyed has yet to be defined fully. Using a new porphyrin sensitizer, benzoporphyrin derivative (BPD), we examined protein expression in murine tumor cells following treatment as an indication of molecular changes to target tissue concurrent with PDT-mediated damage. In order to assess the relevance of the results obtained using an in vitro PDT model, metabolic labeling of proteins synthesized subsequent to PDT was performed both in tumor cells grown and treated in tissue culture dishes and in cells explanted from PDT-treated solid tumors. We observed that the oxidative stress associated with PDT-resulted in the induction of a number of proteins corresponding to a set of heat-shock or stress proteins, and that the pattern of expression was similar when tumor cells were treated in vitro and in vivo. These results support the use of in vitro models in the dissection of the molecular effects of PDT and provide the foundation for future experiments that will examine the role of the immune system in tumor eradication by PDT.

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Immune Response Following Photodynamic Therapy For Bladder Cancer

Cited by 2 publications

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Bibliometric analysis of photodynamic therapy and immune response from 1989–2023

Bibliometric analysis of photodynamic therapy and immune response from 1989–2023

Stress Protein Expression in Murine Tumor Cells Following Photodynamic Therapy With Benzoporphyrin Derivative

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