Immune response enhancement with GLS-5310 DNA primary vaccine against SARS-CoV-2 followed by administration of an mRNA vaccine heterologous boost

Roberts, Christine C.; Song, Joon Young; Yoon, Jin Gu; Seong, Hye; Hyun, Hakjun; Lee, Hyojin; Gil, Areum; Oh, Ye-Eun; Park, Ji‐Eun; Lee, Jieun; Jeon, Bohyun; Kane, D. M.; Spruill, Susan E.; Kudchodkar, Sagar B.; Muthumani, Kar; Park, Young K.; Kwon, Ijoo; Maslow, Joel N.

doi:10.1016/j.vaccine.2023.06.013

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Vaccine

2023

DOI: 10.1016/j.vaccine.2023.06.013

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Immune response enhancement with GLS-5310 DNA primary vaccine against SARS-CoV-2 followed by administration of an mRNA vaccine heterologous boost

Christine C. Roberts

Joon Young Song

Jin Gu Yoon

et al.

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Cited by 2 publications

References 18 publications

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Tissue Tension and Strain as Indicators of Suction‐mediated Cutaneous DNA Transfection: A Parametric Study

Jhumur,

Lallow,

Nachtigal

et al. 2024

Advanced Therapeutics

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Cutaneous suction‐based transfection is a recently developed technique that is painless and simple‐to‐use for the delivery of DNA for nucleic‐acid‐based vaccines. The technique promises high efficiency for both antigen expression and immunogenicity as demonstrated in both animal studies and human clinical trials. To realize this promise, a parametric study and systematic evaluation of the efficacy of cutaneous suction as a transfection method is performed. Using Green Fluorescent Protein (GFP) plasmid expression as a transfection reporter in a rat model, the expression level as a function of both suction nozzle size and suction pressure is quantified. A numerical model is employed to compute skin deformation in terms of strain, which is used to correlate with GFP expression. Based on these results, two quantities, integrated total strain and tissue tension, are proposed as indicators of expression level that can be used to guide protocol development and optimization. These indicators are also discussed in relation to possible cellular uptake mechanisms.

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Tissue Tension and Strain as Indicators of Suction‐mediated Cutaneous DNA Transfection: A Parametric Study

Jhumur,

Lallow,

Nachtigal

et al. 2024

Advanced Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

Have mRNA vaccines sentenced DNA vaccines to death?

Cagigi,

Douradinha

2023

Expert Review of Vaccines

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Immune response enhancement with GLS-5310 DNA primary vaccine against SARS-CoV-2 followed by administration of an mRNA vaccine heterologous boost

Cited by 2 publications

References 18 publications

Tissue Tension and Strain as Indicators of Suction‐mediated Cutaneous DNA Transfection: A Parametric Study

Tissue Tension and Strain as Indicators of Suction‐mediated Cutaneous DNA Transfection: A Parametric Study

Have mRNA vaccines sentenced DNA vaccines to death?

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