Immune response developing in tumorous organism as a result of immunotherapy. Chance of recovery?

Vértesi, Cs.

doi:10.1016/0306-9877(93)90214-b

Cited by 11 publications

(10 citation statements)

References 39 publications

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“…9 Furthermore, S-allyl-GTU has been tested as a promising immunostimulant and tumor inhibitor. 10,11 In addition to that GTU is extensively used in industry because of its special structure. It enables to be used in the synthesis of anion-caged supramolecular compounds 12 and in vulcanization of natural rubber.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The derivative of thiourea, such as N , N ′-dimethylthiourea (DMTU), is, for example, a well-known and effective scavenger of toxic oxygen metabolites, removing rapidly in vitro hydrogen peroxide, hydroxyl radicals, and hypochlorous acid. − Another medically important derivative of thiourea is guanylthiourea (GTU) which is generally used as a stimulator of intestinal peristalsis . Furthermore, S -allyl-GTU has been tested as a promising immunostimulant and tumor inhibitor. , In addition to that GTU is extensively used in industry because of its special structure. It enables to be used in the synthesis of anion-caged supramolecular compounds and in vulcanization of natural rubber. , As seen, these species are extensively involved in biological and technological processes and they are considered as reactive agents; therefore, a firm knowledge of the fundamental background of their redox transformations is eagerly expected.…”

Section: Introductionmentioning

confidence: 99%

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Exact Concentration Dependence of the Landolt Time in the Thiourea Dioxide–Bromate Substrate-Depletive Clock Reaction

et al. 2019

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The thiourea dioxide (TDO)–bromate reaction has been reinvestigated spectrophotometrically under acidic conditions using phosphoric acid–dihydrogen-phosphate buffer within the pH range of 1.1–1.8 at 1.0 M ionic strength adjusted by sodium perchlorate and at 25 °C. The title system shows a remarkable resemblance to the classical Landolt reaction, namely, the clock species (bromine) may only appear after the substrate TDO is completely consumed. Thus, the title system can be classified as substrate-depletive clock reaction. Despite the well-known slow rearrangement characteristic of TDO in acidic solution, it is surprisingly found that the Landolt time of the title reaction does not depend at all on the age of TDO solution applied. It is, however, shown experimentally that the inverse of Landolt time linearly depends on the initial bromate concentration as well as on the square of the hydrogen ion concentration. In addition to this, it is also noticed that dihydrogen phosphate markedly affects the Landolt time as well, and this feature may easily be taken into consideration by the H2PO4 – dependence of the rate of bromate–bromide reaction quantitatively. Based on the experiments, a simple three-step kinetic model is proposed from which a complex formula is derived to indicate the exact concentration dependence of the Landolt time.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exact Concentration Dependence of the Landolt Time in the Thiourea Dioxide–Bromate Substrate-Depletive Clock Reaction

et al. 2019

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“…GTU and its derivatives have been reported to exhibit therapeutic influence in several human diseases. Vertesi1 reported immuno stimulant and tumor cell inhibitory activities of S ‐allyl derivatives of GTU. Kathleen and Davis reported radio protective activity of GTU‐p‐toluenesulfonate salt 2.…”

Section: Introductionmentioning

confidence: 99%

Electronic structure and reactivity of guanylthiourea: A quantum chemical study

et al. 2009

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Electronic structure analysis of guanylthiourea (GTU) and its isomers has been carried out using quantum chemical methods. Two major tautomeric classes (thione and thiol) have been identified on the potential energy (PE) surface. In both the cases conjugation of pi-electrons and intramolecular H-bonds have been found to play a stabilizing role. Various isomers of GTU on its PE surface have been analyzed in two different groups (thione and thiol). The interconversion from the most stable thione conformer (GTU-1) to the most stable thiol conformer (GTU-t1) was found to take place via bimolecular process which involves protonation at sulfur atom of GTU-1 followed by subsequent C-N bond rotation and deprotonation. The detailed analysis of the protonation has been carried out in gas phase and aqueous phase (using CPMC model). Sulfur atom (S1) was found to be the preferred protonation site (over N4) in GTU-1 in gas phase whereas N4 was found to be the preferred site of protonation in aqueous medium. The mechanism of S-alkylation reaction in GTU has also been studied. The formation of alkylated analogs of thiol isomers (alkylated guanylthiourea) is believed to take place via bimolecular process which involves alkyl cation attack at S atom followed by C-N bond rotation and deprotonation. The reactive intermediate RS(NH(2))C-N-C(NH(2))(2)(+) belongs to the newly identified [symbol: see text]N(<--L)(2) class of species and provides the necessary dynamism for easy conversion of thione to thiol.

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“…Guanylthiourea derivatives have immuno-stimulant and tumor cell inhibitory activity 36 and can significantly inhibit dihydrofolate reductase (DHFR). 37 Guanylthiourea is introduced into the structure of ion-exchange/coordinating resins having a vinylbenzyl chloride/divinylbenzene matrix in order to detect metal cations.…”

Section: Applications Of Guanylthioureasmentioning

confidence: 99%