Immune Response- Associated Neopterin Release: An Overview

Huber, Christoph; Troppmair, J.

doi:10.1515/9783110860566-026

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“…lymphocytes and monocytes, plasma levels of neopterin and sCD8 antigen were analysed in all patients. Neopterin is a pyrazinopyramidine compound derived from guanosine triphosphate within the biosynthetic pathway of tetrahydrobiopterin [20]. Monocytes/ macrophages seem to be the major source of neopterin in humans and increased plasma levels are thought to reflect hyperactivity of these cells [20,21].…”

Section: Lymphocyte Subpopulations and Monocytes In Peripheral Blood mentioning

confidence: 99%

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

1997

Transfusion Medicine Reviews

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In 12 patients with primary hypogammaglobulinaemia we investigated the in vivo effect of one bolus injection (400 mg/kg) of intravenous immunoglobulin (IVIG) on lymphocyte subsets and monocytes in peripheral blood, on plasma levels of soluble factors reflecting monocyte and lymphocyte activity and on lymphocyte proliferation and generation of reactive oxygen species (ROS) from monocytes analysed in vitro. Several immunological changes were induced by IVIG infusion. First, there was a significant decrease in CD4 þ /CD8 þ lymphocyte ratio in peripheral blood, reflecting a significant increase in circulating numbers of CD8 þ lymphocytes. Second, although there was no significant change in plasma levels of soluble CD8 antigen, there was a significant decrease in soluble CD8 antigen/CD8 þ lymphocyte ratio, suggesting a down-regulation of CD8 þ lymphocyte activity. Third, there was a significant increase in plasma levels of neopterin, suggesting in vivo activation of monocytes/ macrophages. Fourth, the was a down-modulation of mitogen-stimulated lymphocyte proliferation in vitro, and this down-regulation was significantly correlated with the increase in plasma neopterin levels. Finally, there was a significant decrease in zymosan-stimulated, but not in phorbol myristate acetatestimulated, ROS generation from monocytes as evaluated by nitroblue tetrazolium reduction. The ability of IVIG administration in vivo to down-modulate lymphocyte proliferation and ROS generation from monocytes in patients with persistent immune activation may be relevant for the clinical effects of IVIG in a variety of immune-mediated disorders. Keywords intravenous immunoglobulin lymphocyte proliferation reactive oxygen species neopterin soluble CD8 antigen

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Section: Lymphocyte Subpopulations and Monocytes In Peripheral Blood mentioning

confidence: 99%

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

1997

Transfusion Medicine Reviews

View full text Add to dashboard Cite

show abstract

Immune Response- Associated Neopterin Release: An Overview

Cited by 1 publication

References 0 publications

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

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