Immune Response and Trypanosoma Cruzi Infection in Trypanosoma Rangeli-Immunized Mice

Basso, Beatriz; Moretti, Edgardo; Vottero-Cima, E

doi:10.4269/ajtmh.1991.44.413

Cited by 28 publications

(36 citation statements)

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“…For endemic regions in Panama, T. rangeli is more frequently found in human blood than T. cruzi 23 . In this sense, recent data have shown that complete or partial immunity against T. cruzi can be obtained in animal models previously immunized with low virulent T. cruzi strains 5,9 or with T. rangeli 1,29 . The fact that more than one T. cruzi strain 10,16 and even more than one Trypanosoma species 6,23 can be transmitted by R. pallescens in Panama makes this possibility feasible.…”

Section: Discussionmentioning

confidence: 99%

Eco-epidemiological aspects of Trypanosoma cruzi, Trypanosoma rangeli and their vector (Rhodnius pallescens) in Panama

Vasquez

Samudio

Saldaña

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe eco-epidemiology of T. cruzi infection was investigated in the Eastern border of the Panama Canal in Central Panama. Between 1999 and 2000, 1110 triatomines were collected: 1050 triatomines (94.6%) from palm trees, 27 (2.4%) from periurban habitats and 33 (3.0%) inside houses. All specimens were identified as R. pallescens. There was no evidence of vector domiciliation. Salivary glands from 380 R. pallescens revealed a trypanosome natural infection rate of 7.6%, while rectal ampoule content from 373 triatomines was 45%. Isoenzyme profiles on isolated trypanosomes demonstrated that 85.4% (n = 88) were T. cruzi and 14.6% (n = 15) were T. rangeli. Blood meal analysis from 829 R. pallescens demonstrated a zoophilic vector behavior, with opossums as the preferential blood source. Seroprevalence in human samples from both study sites was less than 2%. Our results demonstrate that T. cruzi survives in the area in balanced association with R. pallescens, and with several different species of mammals in their natural niches. However, the area is an imminent risk of infection for its population, consequently it is important to implement a community educational program regarding disease knowledge and control measures.

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Section: Discussionmentioning

confidence: 99%

Eco-epidemiological aspects of Trypanosoma cruzi, Trypanosoma rangeli and their vector (Rhodnius pallescens) in Panama

Vasquez

Samudio

Saldaña

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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“…On the other hand, mice immunized with fixed T. rangeli epimastigotes had significantly lower parasitemias and longer survival than controls when infected with virulent T. cruzi trypomastigotes (Basso et al 1991, Introini et al 1998). …”

Section: Discussionmentioning

confidence: 99%

Action of Trypanosoma rangeli in infections with virulent Trypanosoma cruzi populations

Palau

Mejía

Vergara

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…Although considered non-pathogenic to man [1], T. rangeli is of medical interest as a possible source of confusion in the serological diagnosis of Chagas' disease due to its well-known immunological cross-reactivity with T. cruzi [2][3][4][5]. In experimental infection of mice, several exposures to T. rangeli cause an increase in antibody titres to T. cruzi and it is possible that these antibodies modulate the outcome of active T. cruzi infection [6][7][8][9]. In support of this notion, Chagas' disease acquires its mildest clinical manifestation precisely in geographical areas in which insect vectors of Chagas' disease have high infection rates with T. rangeli [10].…”

Section: Introductionmentioning

confidence: 99%

Serological Diagnosis of Trypanosoma rangeli Infected Patients. A Comparison of Different Methods and its Implications for the Diagnosis of Chagas' Disease

Krusnell

A³

et al. 1997

Scand J Immunol

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Vásquez JE, Krusnell J, Ö rn A, Sousa OE, Harris RA. Serological Diagnosis of Trypanosoma rangeli Infected Patients. A Comparison of Different Methods and its Implications for the Diagnosis of Chagas' Disease. Scand J Immunol 1997;45:322-330 Venous blood from 65 Panamanian schoolchildren living in an area endemic for both Trypanosoma cruzi and T. rangeli were screened for the presence of these parasites. Trypanosoma rangeli were isolated and cultured from four individuals. Serological tests of all 65 sera were performed, including immunohaemagglutination (IHA), indirect immunofluorescence assay (IF) and ELISA using both T. rangeli and T. cruzi as antigens, as well as T. cruzi synthetic peptides in an ELISA assay. Results indicated a higher immunoreactivity to T. rangeli preparations than to T. cruzi within the studied population, which could be divided into four 'serological responder' groups. Interestingly, the panel of SAPA and other T. cruzi synthetic peptides were not useful in the discrimination of patients. Furthermore, patients from whom parasites had been isolated could not be distinguished from those of two other groups. Significant immunoreactivity to T. cruzi preparations was displayed in all responder sera, despite total lack of evidence of infection with this parasite. The immunobiological significance of T. rangeli infection is unclear, but these data indicate that it is a compounding problem in the accurate diagnosis of pathological T. cruzi infection by serological analysis. The relationship of these cohabiting species, in respect to infection outcome and immunological activation, is discussed.

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Immune Response and Trypanosoma Cruzi Infection in Trypanosoma Rangeli-Immunized Mice

Cited by 28 publications

References 0 publications

Eco-epidemiological aspects of Trypanosoma cruzi, Trypanosoma rangeli and their vector (Rhodnius pallescens) in Panama

Eco-epidemiological aspects of Trypanosoma cruzi, Trypanosoma rangeli and their vector (Rhodnius pallescens) in Panama

Action of Trypanosoma rangeli in infections with virulent Trypanosoma cruzi populations

Serological Diagnosis of Trypanosoma rangeli Infected Patients. A Comparison of Different Methods and its Implications for the Diagnosis of Chagas' Disease

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