Immune Response and Immunologic Memory in Medical Personnel Vaccinated with Hepatitis B Vaccine

Kevorkyan, Аni; Teoharov, Pavel; Petrova, Nedyalka; Baltadzhiev, Ivan; Stoilova, Y.; Angelova, Nevena G.; Plachkova, Angelina D

doi:10.2478/v10153-011-0054-1

Cited by 6 publications

(6 citation statements)

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“…Aside from those factors, patients with concomitant disease usually have a complicated and inconstant status due to diverse pathogenesis. Although some researches found no association between comorbidity and seroprotection 36 37 , comorbidity may be a significant element decreasing the efficacy of hepatitis B vaccine from this analysis and others 23 27 , which could bring immunity disturbance. However, the detailed mechanisms between the poor response to hepatitis B vaccine and adults suffering from concomitant disease are still incompletely understood.…”

Section: Discussioncontrasting

confidence: 53%

“…A previous meta-analysis in 2002 observed many factors influencing response to hepatitis B vaccine, especially a decrease response to recombinant HBV vaccine at higher ages11, which suggested that earlier vaccination should be prioritized for prevention at the population level. However, in the last decade, numerous emerging reports, which focused on the seroprotection rate of hepatitis B vaccine in adults12131415161718192021222324252627282930313233343536373839404142434445464748, are still inconclusive to immunize what adults are the most appropriate in order to increase the seroprotection rate. Factors influencing immunologic response to hepatitis B vaccine in adults have been inconsistently examined in existing studies.…”

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confidence: 99%

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Factors influencing immunologic response to hepatitis B vaccine in adults

Yang

Tian

Cui

et al. 2016

Sci Rep

127

112

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Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55–2.23), male adults (RR:1.40, 95% CI:1.22–1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12–2.17), smoker (RR:1.53, 95% CI:1.21–1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04–1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48–2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01–1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64–1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41–4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended.

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Section: Discussioncontrasting

confidence: 53%

mentioning

confidence: 99%

Factors influencing immunologic response to hepatitis B vaccine in adults

Yang

Tian

Cui

et al. 2016

Sci Rep

127

112

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“…There have been studies demonstrating that postvaccinal immunity against hepatitis B is not only humoral, but it has been detected that immunologic memory determined by HBsAg -specific T-lymphocytes persists long time after vaccination in recipients with serum antibodies <10 mIU/ ml. 20 We have found better immune response after application of hepatitis B vaccine among female gender compared to male gender, as per most of the authors. Men have a reduced response to conventional hepatitis B vaccines.…”

Section: Discussionsupporting

confidence: 59%

Evaluation of Anti-HBs Antibody Immune Response against Hepatitis B virus in Vaccinated People in а North-eastern Bulgaria Region

Tsaneva

Ivanova

Pavlova

et al. 2019

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Citation: Tsaneva-Damyanova DT, Ivanova LI, Pavlova SN, Todorova SB, Popova TK. Evaluation of anti-HBs antibody immune response against hepatitis B virus in vaccinated people in North-Eastern Bulgaria region. Folia Med (Plovdiv) 2019;61(4):572-78. doi: 10.3897/ folmed.61.e47760. AbstractIntroduction: Hepatitis B virus (HBV) is one of the most significant human pathogens responsible for a huge number of acute and chronic liver infectious diseases worldwide.Aim: To find the duration of post-vaccination immune response in individuals allocated to five age groups from 6 months to 20 years.Materials and methods: All tested subjects were born between 1999 and 2018 and therefore covered by the compulsory vaccination program against hepatitis B. For the serological marker anti-HBs Ab we investigated 449 serum samples taken from ambulatory people and patients of St Marina University Hospital in Varna. Results:A positive antibody response (anti-HBs Ab > 10 mIU/ml) was reported in 79.7% (n = 51) of the group of subjects up to one year old, in 70.0% (n = 196) of the subjects in the age range 1 year/1 month to 15 years, and in 39.3% (n = 33) of the subjects 15 years/1 month to 20 years old. Female sex had a better post-vaccination response than male sex with statistically significant relationship between sex and anti-HBs Ab titer (χ 2 = 24.76, p <0.01). Conclusions:Regardless of the mass immunization against HBV in Bulgaria, the relative share of chronic HBV infections does not show a downward trend. Therefore, it is very important to study the duration of the post-vaccination immune response by demonstrating the anti-HBs antibodies and to apply a booster dose from the vaccine if needed.

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“…17,18 Fifth, improved control and implementation of hepatitis B virus vaccine. [19][20][21][22][23] Sixth, the results from the study could be influenced by disorders in medical statistics.…”

Section: Discussionmentioning

confidence: 99%

Trends in the Acute Hepatitis B and Acute Hepatitis C in Bulgaria

Baymakova

Karcheva

2019

Folia Medica

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Introduction: Bulgaria joined European Union (EU) on 1 January 2007. Since the accession all regulations, directives, decisions, recommendations, and opinions of the European Parliament, the Council of the European Union, and the European Commission are being implemented. Aim: The purpose of this study was to present the morbidity of acute hepatitis B virus (HBV) and acute hepatitis C virus (HCV) in Bulgaria before and after accession to the EU. Materials and methods: A retrospective study was performed. The morbidity of acute HBV and acute HCV infections in Bulgaria was analyzed over a period of sixteen years (2000−2016). The collected data were based on the National Center of Infectious and Parasitic Diseases (NCIPD) and the National Center of Public Health and Analyses (NCPHA). Results: Between 2000 and 2016, 11038 cases of acute HBV infection and 1681 cases of acute HCV infection were reported in Bulgaria. Before the accession to EU, the morbidity rates of acute HBV and acute HCV infections were 12.77 cases per 100 000 population (95% CI: 11.45–13.97) and 1.52 cases per 100 000 population (95% CI: 1.17–1.96), respectively. After the accession to the EU, the morbidity rates of acute HBV and acute HCV infections were 5.29 cases per 100 000 population (95% CI: 3.86–6.73) and 1.14 cases per 100 000 population, respectively. Conclusion: Analysis of the data suggests that there is a tendency for lower morbidity rates of acute HBV. The situation with acute HCV is relatively stable over the years regardless of EU membership.

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Immune Response and Immunologic Memory in Medical Personnel Vaccinated with Hepatitis B Vaccine

Abstract: ABSTRACT

Cited by 6 publications

References 10 publications

Factors influencing immunologic response to hepatitis B vaccine in adults

Factors influencing immunologic response to hepatitis B vaccine in adults

Evaluation of Anti-HBs Antibody Immune Response against Hepatitis B virus in Vaccinated People in а North-eastern Bulgaria Region

Trends in the Acute Hepatitis B and Acute Hepatitis C in Bulgaria

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Immune Response and Immunologic Memory in Medical Personnel Vaccinated with Hepatitis B Vaccine

Abstract: ABSTRACT

Cited by 6 publications

References 10 publications

Factors influencing immunologic response to hepatitis B vaccine in adults

Factors influencing immunologic response to hepatitis B vaccine in adults

Evaluation of Anti-HBs Antibody Immune Response against Hepatitis B virus in Vaccinated People in &#1072; North-eastern Bulgaria Region

Trends in the Acute Hepatitis B and Acute Hepatitis C in Bulgaria

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Evaluation of Anti-HBs Antibody Immune Response against Hepatitis B virus in Vaccinated People in а North-eastern Bulgaria Region