Immune repertoire: A potential biomarker and therapeutic for hepatocellular carcinoma

Han, Yingxin; Li, Hongmei; Guan, Yanfang; Huang, Jian

doi:10.1016/j.canlet.2015.06.022

Cited by 32 publications

(22 citation statements)

References 112 publications

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“…Given the large size of the dataset (we began with nearly 40000 unique motifs and, during clustering, performed more than 142 million pairwise comparisons), it is difficult to say whether these enriched motifs constitute meaningful biological reality or whether they represent an artifact of analyzing data on such a large scale. A larger cohort of ADCLS and CFS cases and controls with longitudinal sampling is needed to explore whether the observed associations between motifs and disease phenotype remain significant and whether these TCR/BCR motifs constitute useful disease biomarkers, as previously shown for cancer [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease

Bouquet

Gardy

Brown

et al. 2017

Clinical Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease

Bouquet

Gardy

Brown

et al. 2017

Clinical Infectious Diseases

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“…Recently, a series of studies have characterized the signatures of T cell repertoires in patients with various types of cancer using high throughput T cell receptor (TCR) sequencing and confirmed that TCR repertoire could sever as a biomarker for monitoring immune response ( 7 – 9 ). However, the characteristics of TCR repertoire including diversity and similarity, as well as its prognostic significance in CC patients remain unknown.…”

Section: Introductionmentioning

confidence: 99%

TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer

et al. 2018

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There is increasing evidence that deep sequencing-based T cell repertoire can sever as a biomarker of immune response in cancer patients; however, the characteristics of T cell repertoire including diversity and similarity, as well as its prognostic significance in patients with cervical cancer (CC) remain unknown. In this study, we applied a high throughput T cell receptor (TCR) sequencing method to characterize the T cell repertoires of peripheral blood samples from 25 CC patients, 30 cervical intraepithelial neoplasia (CIN) patients and 20 healthy women for understanding the immune alterations during the cervix carcinogenesis. In addition, we also explored the signatures of TCR repertoires in the cervical tumor tissues and paired sentinel lymph nodes from 16 CC patients and their potential value in predicting the prognosis of patients. Our results revealed that the diversity of circulating TCR repertoire gradually decreased during the cervix carcinogenesis and progression, but the circulating TCR repertoires in CC patients were more similar to CIN patients than healthy women. Interestingly, several clonotypes uniquely detected in CC patients tended to share similar CDR3 motifs, which differed from those observed in CIN patients. In addition, the TCR repertoire diversity in sentinel lymphatic nodes from CC patients was higher than in tumor tissues. More importantly, less clonotypes in TCR repertoire of sentinel lymphatic node was associated with the poor prognosis of the patients. Overall, our findings suggested that TCR repertoire might be a potential indicator of immune monitoring and a biomarker for predicting the prognosis of CC patients. Although functional studies of T cell populations are clearly required, this study have expanded our understanding of T cell immunity during the development of CC and provided an experimental basis for further studies on its pathogenesis and immunotherapy.

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“…Human adaptive immunity is mediated by leukocytes, including B and T cells, which have been demonstrated to be selectively activated by interactions between antigens and their receptors expressed on the surface of lymphocytes ( 9 ). Therefore, understanding the spectrum of antigen receptors present on B and T cells, known as the immune repertoire, may aid in identifying biomarkers and the development of therapeutics for IgAN ( 10 ). In the antigen-binding site of B-cell receptors (BCRs)/T-cell receptors (TCRs), specific recognition of countless diverse peptide-major histocompatibility complexes are determined by three complementarity-determining regions (CDRs): CDR1, CDR2 and CDR3.…”

Section: Introductionmentioning

confidence: 99%

Integrated analysis of B‑cell and T‑cell receptors by high‑throughput sequencing reveals conserved repertoires in IgA nephropathy

Zheng

Zhang

et al. 2018

Mol Med Report

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Immunoglobulin A nephropathy (IgAN) is a type of glomerular disorder associated with immune dysregulation, and understanding B-/T-cell receptors (BCRs/TCRs) may be valuable for the development of specific immunotherapeutic interventions. In the present study, B and T cells were isolated from IgAN patients and healthy controls, and the composition of the BCR/TCR complementarity-determining region (CDR)3 was analyzed by multiplex polymerase chain reaction, high-throughput sequencing and bioinformatics. The present results revealed that the BCR/TCR CDR3 clones were expressed at very low frequencies, and the composition of clone types in patients with IgAN was skewed; the majority of clones were unique, and only 12 BCR and 228 TCR CDR3 clones were public ones, of which 16 were expressed at a significantly higher frequency in patients with IgAN (P<0.001). There were also certain conserved amino acid residues between unique clones or groups, and the residues GMDV, EQY and EQF were recurring only in the IgAN group. In addition, some VDJ gene recombinations indicated great variation between groups, including 4 high-frequency VDJ gene recombinations in the IgAN patients (P<0.001). Immune repertoires provide novel information, and conserved BCR/TCR CDR3 clones and VDJ gene recombinations with great variation may be potential therapeutic targets for IgAN patients.

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Immune repertoire: A potential biomarker and therapeutic for hepatocellular carcinoma

Cited by 32 publications

References 112 publications

RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease

RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease

TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer

Integrated analysis of B‑cell and T‑cell receptors by high‑throughput sequencing reveals conserved repertoires in IgA nephropathy

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