Immune-Related Functions of Heme Oxygenase-1

Lianos, Elias A.; Detsika, Maria G.

doi:10.3390/antiox12071322

Antioxidants

2023

DOI: 10.3390/antiox12071322

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Immune-Related Functions of Heme Oxygenase-1

Elias A. Lianos

Maria G. Detsika

Abstract: Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]

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2024

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Erythropoietin Effect on Complement Activation in Chronic Kidney Disease

Athanasiadou,

Ampelakiotou,

Grigoriou

et al. 2024

Biomedicines

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The complement system is an important part of innate immunity. Despite its known protective role, the complement system may contribute to increased inflammation and tissue injury in cases where its balanced activation is disrupted. The kidneys have been shown to be largely affected by complement dysregulation. The aim of the present study was to investigate the effect of erythropoietin administration, on the complement system, in chronic kidney disease patients. The study involved 20 patients with CKD who received erythropoietin and measurements of levels of complement factors C3a and C5a and complement regulatory proteins (CregPs) CD55, CD46, and CD59. An increase in serum C3a and C5a levels was observed in response to EPO therapy. The increase in C3a was statistically significant (p < 0.05) and concurrent with a statistically significant decrease in CD55 in CD4+ T cells (p < 0.05) and B cells (p < 0.05) and CD59 levels in CD4+ and CD8+ T cells (p < 0.05) at completion of EPO therapy compared with healthy controls. The above observations demonstrate that EPO induces complement activation in patients undergoing EPO therapy with a simultaneous restriction of CRegPs expression, thus possibly allowing the uncontrolled complement activation, which may contribute to tissue injury and disease progression.

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Erythropoietin Effect on Complement Activation in Chronic Kidney Disease

Athanasiadou,

Ampelakiotou,

Grigoriou

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Immune-Related Functions of Heme Oxygenase-1

Abstract: Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]

Cited by 1 publication

References 12 publications

Erythropoietin Effect on Complement Activation in Chronic Kidney Disease

Erythropoietin Effect on Complement Activation in Chronic Kidney Disease

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