Immune Regulation of Tumor Immunity by NKT Cells

O’Konek, Jessica J.; Berzofsky, Jay A.; Terabe, Masaki

doi:10.1007/978-1-4614-0613-6_4

Cited by 1 publication

(1 citation statement)

References 113 publications

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“…Due to their cytokine production, iNKT cells can have a pronounced effect on the immune system, impacting a dazzling variety of different immune reactions. They are involved in a range of chronic and acute inflammatory processes including responses to pathogens (Kinjo and Kronenberg 2009) and tumors (O'Konek et al 2012), as well as in allergic (Berzins and Ritchie 2014;DeKruyff et al 2014) and autoimmune responses (Simoni et al 2013;Wingender and Kronenberg 2014).…”

Section: Introductionmentioning

confidence: 99%

From the Deep Sea to Everywhere: Environmental Antigens for iNKT Cells

Wingender

2015

Arch. Immunol. Ther. Exp.

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Invariant natural killer T (iNKT) cells are a unique subset of innate T cells that share features with innate NK cells and adaptive memory T cells. The first iNKT cell antigen described was found 1993 in a marine sponge and it took over 10 years for other, bacterial antigens to be described. Given the paucity of known bacterial iNKT cell antigens, it appeared as if iNKT cells play a very specialist role in the protection against few, rare and unusual pathogenic bacteria. However, in the last few years several publications painted a very different picture, suggesting that antigens for iNKT cells are found almost ubiquitous in the environment. These environmental iNKT cell antigens can shape the distribution, phenotype and function of iNKT cells. Here, these recent findings will be reviewed and their implications for the field will be outlined.

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Section: Introductionmentioning

confidence: 99%

From the Deep Sea to Everywhere: Environmental Antigens for iNKT Cells

Wingender

2015

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

show abstract

Immune Regulation of Tumor Immunity by NKT Cells

Cited by 1 publication

References 113 publications

From the Deep Sea to Everywhere: Environmental Antigens for iNKT Cells

From the Deep Sea to Everywhere: Environmental Antigens for iNKT Cells

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