Immune regulation by non-lymphoid cells in transplantation

Dugast, Anne‐Sophie; Vanhove, Bernard

doi:10.1111/j.1365-2249.2009.03877.x

Cited by 23 publications

(12 citation statements)

References 140 publications

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“…Additionally, activin A production by SCs and its involvement in inducing alternatively activated testicular macrophages has been reported [71]. Alternatively activated macrophages are involved in wound repair, tissue remodeling, reducing inflammation and modulating the immune response [72]. These are just few examples of immunoregulatory factors expressed by SCs.…”

Section: Immune Modulation/tolerance By the Sertoli Cellsmentioning

confidence: 99%

Sertoli cells – Immunological sentinels of spermatogenesis

Kaur

Thompson

Dufour

2014

Seminars in Cell & Developmental Biology

207

161

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Testicular germ cells, which appear after the establishment of central tolerance, express novel cell surface and intracellular proteins that can be recognized as ‘foreign antigens’ by the host’s immune system. However, normally these germ cells do not evoke an auto-reactive immune response. The focus of this manuscript is to review the evidence that the Blood-Testis-Barrier (BTB)/Sertoli cell (SC) barrier along with the SCs ability to modulate the immune response is vital for protecting auto-antigenic germ cells. In normal testis, the BTB/SC barrier protects the majority of the auto-antigenic germ cells by limiting access by the immune system and sequestering these ‘new antigens’. SCs also modulate testis immune cells (induce regulatory immune cells) by expressing several immunoregulatory factors, thereby creating a local tolerogenic environment optimal for survival of nonsequesetred auto-antigenic germ cells. Collectively, the fortress created by the BTB/SC barrier along with modulation of the immune response is pivotal for completion of spermatogenesis and species survival.

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Section: Immune Modulation/tolerance By the Sertoli Cellsmentioning

confidence: 99%

Sertoli cells – Immunological sentinels of spermatogenesis

Kaur

Thompson

Dufour

2014

Seminars in Cell & Developmental Biology

207

161

View full text Add to dashboard Cite

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“…Studies on tumor immunity and transplantation have indicated that APCs are not only engaged in the initiation of inflammatory reactions but also contribute to the development of peripheral tolerance, leading to immunoevasion of cancer cells and the establishment of allograft tolerance. [4][5][6] The great versatility in macrophage-mediated regulation of immune responses lies in the ability of these APCs to alter their antigen-presenting and cytokine secretion functions in response to organ-specific microenvironments. This allows macrophages to participate in a very wide range of biological process, including inflammation and tissue remodeling.…”

Section: Introductionmentioning

confidence: 99%

The Immunomodulatory Roles of Macrophages at the Maternal—Fetal Interface

2010

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Macrophages are versatile cells that play a central role in innate and adaptive immunity and participate in a wide variety of biological processes. In the uterine decidua, macrophages represent a major leukocyte subset throughout pregnancy. Here, decidual macrophages exert an immunosuppressive phenotype characterized by abundant production of interleukin (IL)-10 and indoleamine 2,3-dioxygenase activity. Their polarized cytokine secretion pattern has recently been classified as an M2 phenotype. These features of decidual macrophages favor maternal immune tolerance to semiallogenic fetus. In addition, macrophages cooperate with trophoblast cells during the early stages of human pregnancy to support uterine vasculature remodeling by removing apoptotic cells and through the production of proteases that degrade the extracellular matrix. In the peripartum period, macrophages also participate in the regulation of cervical ripening and the initiation of parturition through the production of proinflammatory cytokines and prostaglandin E(2) (PGE(2)). Aberrant activity of uterine macrophages is linked to the pathogenesis of preeclampsia and preterm delivery. Here, we review the immunomodulatory roles of decidual macrophages during pregnancy.

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“…14,39–42 There is evidence however, that IFNγ-generated regulatory APCs can promote T reg development, a factor more likely in longer term, in vivo models of T cell tolerance. 43,44 …”

Section: Discussionmentioning

confidence: 99%

CD28 ligation increases macrophage suppression of T-cell proliferation

et al. 2012

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When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T cell activation in vitro. The greater proportional representation of macrophages in this cell source has been shown to actively suppress the T cell response. Peritoneal macrophages exhibit an immature phenotype (MHC Class IIlo, B7lo) that reduces their efficacy as antigen presenting cells. Furthermore, these cells readily express inducible nitric oxide synthase (iNOS), an enzyme that promotes T cell tolerance by catabolism of the limiting amino acid arginine. Here, we investigate the ability of exogenous T cell costimulation to recover the peritoneal T cell response. We show that CD28 ligation failed to recover the peritoneal T cell response and actually suppressed responses that had been recovered by inhibiting iNOS. As indicated by cytokine ELISpot and neutralizing mAb treatment, this “co-suppression” response was due to CD28 ligation increasing the number of IFNγ-secreting cells. Our results illustrate that cellular composition and cytokine milieu influence T cell costimulation biology.

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Immune regulation by non-lymphoid cells in transplantation

Cited by 23 publications

References 140 publications

Sertoli cells – Immunological sentinels of spermatogenesis

Sertoli cells – Immunological sentinels of spermatogenesis

The Immunomodulatory Roles of Macrophages at the Maternal—Fetal Interface

CD28 ligation increases macrophage suppression of T-cell proliferation

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