Immune regulation: a new role for the CD8+ T cell

Kemeny, David M.; Noble, Alistair; Holmes, Barbara E.; Díaz-Sánchez, David

doi:10.1016/0167-5699(94)90152-x

Cited by 173 publications

(77 citation statements)

References 34 publications

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“…ϩ T cells play an important role in regulation of the humoral immune response and isotype switching (23,38,39). Moreover, previous studies from our group have demonstrated that the humoral immune response against most P. brasiliensis components is T-cell dependent (7).…”

Section: Effects Of In Vivo Depletion Of Cd8 ؉ T Cells On Specific Humentioning

confidence: 99%

Depletion of CD8⁺T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

et al. 2000

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Section: Effects Of In Vivo Depletion Of Cd8 ؉ T Cells On Specific Humentioning

confidence: 99%

Depletion of CD8⁺T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

et al. 2000

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“…There is a realization now that a similar functional heterogeneity exists among CD8 + T lymphocytes, and two populations, Tc1 and Tc2, have been described which display cytokine selectivity comparable, respectively, with Th1 and Th2 cells. [18][19][20][21] There are indications that functional subsets of CD8 + lymphocytes, and in particular Tc1-type cells, may play important roles as regulators or effectors of allergic reactions in experimental animals. [22][23][24] In the present investigation we have therefore questioned the extent to which CD8 + T lymphocytes contribute toward the characteristic cytokine secretion patterns that develop in mice exposed to chemical allergens.…”

Section: Introductionmentioning

confidence: 99%

Contribution of CD4⁺ and CD8⁺ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens

et al. 1996

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SUMMARYChemical allergens of different types, those that cause in humans allergic contact dermatitis or occupational asthma, induce in mice divergent immune responses characteristic, respectively, of T-helper 1 (Th1)-and Th2-type cell activation. Such responses are associated with the development of different cytokine secretion patterns by draining lymph node cells (LNC), such that contact allergens stimulate vigorous interferon-g (IFN-g) production, but little secretion of the Th2 cytokines interleukin-4 and interleukin-10 (IL-4 and IL-10), whereas the converse pattern is provoked by respiratory allergens. Using selective depletion with antibody and complement we have here examined the relative contribution of CD4 þ and CD8 þ T lymphocytes to the cytokine secretion patterns of draining LNC isolated from mice sensitized to chemical allergens. Mice received repeated topical applications of respiratory allergens, trimellitic anhydride (TMA) or diphenylmethane diisocyanate (MDI), or of contact allergens 2,4-dinitrochlorobenzene (DNCB) or formaldehyde. Thirteen days following the initiation of exposure the production by draining LNC of IL-10, IFN-g and mitogen (concanavalin A)-inducible IL-4 was measured by enzyme-linked immunosorbent assay (ELISA) after various periods of culture. It was found that the high levels of IL-4 and IL-10 secretion stimulated by TMA or MDI, and the lower levels of these cytokines induced by DNCB or formaldehyde, were in all cases dependent upon the presence of CD4 þ cells. In contrast, the comparatively high concentrations of IFN-g observed following exposure to contact allergens were found to be derived from CD4 þ cells, and in the case of DNCB from CD8 þ cells also. The low levels of IFN-g induced by treatment with TMA or MDI were associated largely or wholly with CD8 þ cells. These data indicate that the type 2 cytokine responses induced to different extents by both contact and respiratory chemical allergens are almost exclusively a function of CD4 þ cells, but that IFN-g is produced by either CD4 þ and CD8 þ cells in the case of contact allergens or largely by CD8 þ cells in the case of chemical respiratory allergens.

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“…T cells which play an important role in the regulation of the immune response [9]. Thus, the increased secretion of sCD8 by jejunal mucosa suggests that ED perfusion could activate mucosal T cells and preferentially CD8…”

Section: Discussionmentioning

confidence: 99%

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

Desreumaux

Levy

Vaerman

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe effects of nutrients on the mucosal immune system are poorly understood. The aim of this work was to study the cellular mucosal immune response to intrajejunal perfusion of an elemental diet (ED) or a control (C) electrolyte solution by measuring jejunal secretion of soluble CD4 (sCD4) and sCD8. sCD4 and sCD8 are markers of helper/inducer and suppressor/cytotoxic regulatory functions of T cells, respectively. A four lumen tube with a proximal occluding balloon at the angle of Treitz was used for jejunal perfusion in seven healthy volunteers (mean age 23 years). The length of the test segment was 40 cm. The jejunum was successively perfused with C for 80 min and then with ED containing 21 . 3 g/l of free amino acids and 104 . 2 g/l of oligosaccharides for 100 min. Jejunal fluid and serum concentrations of sCD4 and sCD8 were measured and their jejunal outputs calculated. When compared with C perfusion, jejunal perfusion with the ED resulted in a significant increase of sCD8 but not sCD4 jejunal secretion rates. sCD8 jejunal values increased early after ED perfusion and stayed at roughly the same level during the perfusion. Serum concentrations of sCD4 and sCD8 were not modified during ED perfusion. These data support the hypothesis that ED suppresses the immunologic tone of the gut, which could explain its beneficial effect in the management of intestinal inflammatory disease.

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Immune regulation: a new role for the CD8+ T cell

Cited by 173 publications

References 34 publications

Depletion of CD8⁺T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

Depletion of CD8⁺T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

Contribution of CD4⁺ and CD8⁺ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

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Immune regulation: a new role for the CD8+ T cell

Cited by 173 publications

References 34 publications

Depletion of CD8+T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

Depletion of CD8+T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

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Depletion of CD8⁺T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

Depletion of CD8⁺T Cells In Vivo Impairs Host Defense of Mice Resistant and Susceptible to Pulmonary Paracoccidioidomycosis

Contribution of CD4⁺ and CD8⁺ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens