2019
DOI: 10.1038/s41582-019-0268-z
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Immune reconstitution therapies: concepts for durable remission in multiple sclerosis

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Cited by 79 publications
(99 citation statements)
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References 88 publications
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“…The impact on memory B cells was similar to the depletion rates found after treatment with injectable CLAD 15 and has been implicated in the long-lasting efficacy of IRTs. 1,9,16,17 We also confirm a selectivity of CLAD towards central memory TH cells. Importantly, a majority of autoreactive cells belong to this very phenotype.…”
Section: Discussionsupporting
confidence: 73%
“…The impact on memory B cells was similar to the depletion rates found after treatment with injectable CLAD 15 and has been implicated in the long-lasting efficacy of IRTs. 1,9,16,17 We also confirm a selectivity of CLAD towards central memory TH cells. Importantly, a majority of autoreactive cells belong to this very phenotype.…”
Section: Discussionsupporting
confidence: 73%
“…Alemtuzumab. Alemtuzumab is a monoclonal antibody to CD52 that leads to depletion of T cells and B cells 99,100 . Treatment impairs cellular and humoral immunity; the extent of impairment depends on the time since the last dose and the number of treatment cycles 101,102 .…”
Section: Immune-depleting and Repopulating Therapies B Cell-depletingmentioning
confidence: 99%
“…Immune reconstitution therapy (IRT) is an emerging concept for the treatment of MS [9,10]. The aim of IRTs is to eliminate a pathogenic immune repertoire through intense short-term immunosuppression, and to subsequently rebuild a new and healthy immune system with the goal to re-establish a persistent immune tolerance [11]. After a period of deep immune depletion, the immune system undergoes reconstitution and radical changes in the lymphocyte repertoire and regains its ability to respond to infections.…”
Section: Introductionmentioning
confidence: 99%