Immune reconstitution and vaccination outcome in HIV-1 infected children

Seroprevalence and vaccination coverage of vaccine-preventable diseases in perinatally HIV-1-infected patients

“…Low seropositivity/ seroprotection rates were observed even in those who currently have their HIV infection well controlled (HIV-RNA ≤ 50 copies/mL and CD4 count ≥ 500 cells/mm 3 ) (data not shown). This finding is consistent with the suboptimal responsiveness and the rapid decline of immunity to childhood vaccinations described in HIV-1 infected children compared with healthy individuals, 13 also in the HAART era. In this regard, we should bear in mind that some patients of our study population were born before and others within the HAART era.…”

“…5,[10][11][12] Moreover, for HIV-infected individuals, appropriate strategies are crucial for identifying those susceptible to preventable infections and prone to severe complications, and for ensuring them adequate protective immunity through the specific immunization schedules in terms of timing and number of vaccine doses rather than undergoing revaccination upon failure of immunization. 13 Background. even in the era of highly active antiretroviral therapy (haaRT), hIV-infected subjects are at higher risk of complications from vaccine-preventable diseases than those uninfected.…”

Defective B-cell proliferation and maintenance of long-term memory in patients with chronic granulomatous disease

“…In addition, 4 of 10 patients had antibody levels of less than protective levels (Fig 4, C), according to standard correlates of seroprotection. 23 Further analyses demonstrated that among patients with CGD, there is an age-related waning of measles serologic immunity (r 5 20.7, P 5 .022; Fig 4, D) not found in HCs (Fig 4, E). All patients with CGD who presented with a lower response after in vitro stimulation for ELISpot assay and serologically unprotected to measles presented common phenotypic characteristics compared with other patients with CGD (Fig 5).…”

Premature ageing of the immune system relates to increased anti-lymphocyte antibodies (ALA) after an immunization in HIV-1-infected and kidney-transplanted patients

“…The modulation of such antibodies after challenging the immune system with vaccination has never been investigated. While the need and effectiveness of flu vaccination in HC is still debated [16], seasonal flu vaccination is recommended for HIV-1-infected individuals [17] and for patients with other immune disorders featuring loss of protective immunity, such as patients undergoing immunosuppressive therapy following solid organ transplantation [18][19][20].…”