Immune-protective, antioxidant and relative genes expression impacts of β-glucan against fipronil toxicity in Nile tilapia, Oreochromis niloticus

El-Murr, Abdelhakeem; Hakim, Yasser Abd El; Neamat‐Allah, Ahmed N. F.; Baeshen, Mohammed N.; Ali, Haytham

doi:10.1016/j.fsi.2019.09.033

Cited by 59 publications

(27 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings for tilapia supplemented with βG and exposed to ATZ indicate that βG protects the liver from injury, as signified by an improvement in ALT and AST and markers of hepatic dysfunction (Khalil et al, ). βG also has hepato‐protective effects against liver damage from other toxicants (Bashir & Choi, ; El‐Murr et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…ATZ‐exposed tilapia showed reductions in immune response features that may be an immunosuppressive effect of ATZ (Kirsten et al, ). Augmentation of these immune features was observed in tilapia supplemented with βG due to its immunomodulating property (El‐Murr et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Our findings for tilapia supplemented with βG and exposed to ATZ indicate that βG protects the liver from injury, as signified by an F I G U R E 2 Influence of dietary supplementation with 0.5 βG g/kg −1 on the relative expression of immune-related gene (IgM) in O. niloticus exposed to ATZ (1/5 96-hr LC 50 ) [Colour figure can be viewed at wileyonlinelibrary.com] F I G U R E 3 Influence of dietary supplementation with 0.5 βG g/kg −1 on the relative expression of antioxidantrelated gene (SOD) in O. niloticus exposed to ATZ (1/5 96-hr LC 50 ) [Colour figure can be viewed at wileyonlinelibrary.com] improvement in ALT and AST and markers of hepatic dysfunction (Khalil et al, 2017). βG also has hepato-protective effects against liver damage from other toxicants (Bashir & Choi, 2017;El-Murr et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…β‐glucan (βG) is known as natural immunomodulator. Indeed, initial studies more than two hundred years ago have reported favourable effects on harmful toxicant and disease progression (El‐Murr, Abd El Hakim, Neamat‐Allah, Baeshen, & Ali, ; Leal et al, ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

Self Cite

View full text Add to dashboard Cite

Three hundred Oreochromis niloticus were divided into five groups; the control fish (CNT) were fed a basal diet, beta glucan (βG) group was fed 0.5 g/kg−1 βG, atrazine (ATZ) group was exposed to 1/5 96‐hr LC50 (1.39 mg/L) ATZ, the (βG/ATZ) group was fed βG while being exposed to ATZ, and the (βG then ATZ) group was supplemented with βG for fifteen days before exposed to ATZ. ATZ exposure caused a decline in growth that was ameliorated by βG. ATZ reduced the levels of total and different types of leucocytes. Additionally, ATZ exposure caused reductions in total proteins, globulins, α 1‐globulin, α 2‐globulin, ɤ‐globulin, immunoglobulin M, lysozymes, superoxide dismutase, nitric oxide and catalase but increases in hepatic transaminases and malondialdehyde without any variations in albumin and β‐globulin. Exposure to ATZ also resulted in a rise in the mRNA level of IL‐8. In contrast, expression of IgM, SOD and CAT were decreased in the tilapias exposed to ATZ. Exposure to ATZ increases the susceptibility response to Aeromonas sobria challenge, as indicated by an increase in cumulative mortality post‐challenge. Supplementation with βG fifteen days before (βG then ATZ group), counteracted the adverse effects of ATZ on the immune, biochemical and antioxidants values, though only slight alleviation was observed with simultaneous treatment (βG/ATZ group). Our results established that ATZ has adverse impacts on immune responses, antioxidant equilibrium and its related genes. While, supplementation with βG before exposure to ATZ may be valuable for counteracting the possible damage caused by ATZ water pollution than its simultaneous treatment with ATZ.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, the activity of some structures from successive negative contrast (SNC) can be impaired as a result of Pyr influence in promoting important alterations of behavior and cognition [ 11 , 68 ]. Regarding a Fip effect on cortisol level, it was showed that administration of 0.0021 and 0.0042 mg L −1 of Fip for 96 h through water and food can increase cortisol level in Nile tilapia ( Oreochromis niloticus ) [ 69 ]. Based on these previous findings, we can conclude that Fip with Pyr may have a synergistic effect on affecting zebrafish swimming performance since in the current study; the combination of these insecticides caused more severe effects.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

et al. 2020

View full text Add to dashboard Cite

Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protective role of vitamin C (Vit. C) from children’s supplements after 14 days chronic exposure to insecticide mixture fipronil (Fip) + pyriproxyfen (Pyr) on juvenile zebrafish for swimming performances, social behavior and oxidative stress associated with ASD model. Juvenile (14–17 mm) wild-type AB zebrafish (Danio rerio) (45 days) were exposed to relevant concentrations: vit. C (25 µg L−1), Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1/1.89 μM), and [Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1 /1.89 μM)] + vit. C (25 µg L−1). Our results showed that insecticides can disturb the social behavior of zebrafish during 14 days of the administration, decreased the swimming performances, and elevated the oxidative stress biomarkers of SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde). The vitamin C supplement significantly attenuated the neurotoxicity of insecticide mixture and oxidative stress. This study provides possible in vivo evidence to show that vitamin C supplements could attenuate oxidative stress and brain damage of fipronil and pyriproxyfen insecticide chronic exposure on zebrafish juvenile.

show abstract

Fipronil impairs the GABAergic brain responses of Nile Tilapia during the transition from normoxia to acute hypoxia

et al. 2022

View full text Add to dashboard Cite

γ‐aminobutyric acid (GABA) is one of the main neurotransmitters involved in the adaptation processes against the damage that hypoxia can cause to the brain. Due to its antagonist action on GABA receptors, the insecticide fipronil can turn the fish more susceptible to the negative effects of hypoxia. This study aimed to understand better if fipronil affects these GABAergic responses of Tilapia ahead to hypoxia. Oreochromis Niloticus (Nile Tilapia) were exposed for 3 and 8 h to fipronil (0.0, 0.1, and 0.5 µg.L−1) under normoxia (dissolved O2 > 6 mg.L−1) and moderate hypoxia (dissolved O2 < 2 mg.L−1) conditions. Briefly, hypoxia caused opposite effects on the gene transcription of the evaluated ionotropic and metabotropic GABA receptors. Unexpectedly, we obtained reduced HIF1A mRNA and brain GABA levels, mostly in the first 3 h of the experiment, for the hypoxic group compared with the normoxia one. Besides that, we also demonstrated that the insecticide fipronil impairs the brain GABAergic signaling of a hypoxia‐tolerant fish during the transition from a normoxic to an acute hypoxic state. Thus, these results predict the relevant impact on the brain metabolic adaptations of fishes exposed to such stressful conditions in an aquatic environment, as well as the effects of fipronil in the GABAergic responses to hypoxia, which in turn may have ecological and physiological significance to hypoxia‐tolerant fishes exposed to this insecticide.

show abstract

Immune-protective, antioxidant and relative genes expression impacts of β-glucan against fipronil toxicity in Nile tilapia, Oreochromis niloticus

Cited by 59 publications

References 63 publications

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

Fipronil impairs the GABAergic brain responses of Nile Tilapia during the transition from normoxia to acute hypoxia

Contact Info

Product

Resources

About