Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer

Héninger, Erika; Sethakorn, Nan; Kosoff, David; Hematti, Peiman; Kuczler, Morgan D.; Pienta, Kenneth J.; Lang, Joshua M.

doi:10.18632/oncotarget.27817

Cited by 1 publication

(2 citation statements)

References 48 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gamma-delta T cells produce IFN-gamma, promote antitumor T cell activity, directly suppress osteoclasts, and have been associated positive clinical outcomes in PC [124]. NKT cells exhibit potent antitumor activity and are greatly reduced in PC tissue [125] and in PC bone marrow [126]. NKT cells rapidly diminish at the periphery after antigen encounter and get replenished in bone marrow.…”

Section: Complex Multicellular Composition Of Bone and Bone Marrow Metastatic Nichesmentioning

confidence: 99%

“…At our institution, we have collaborations with the University of Wisconsin Bone Marrow Transplant Program to obtain bone marrow mononuclear cells from healthy donors, performed clinically for bone marrow donation [305]. We have successfully harvested cells remaining in used filters after bone marrow transplantation yielding sufficient cells for multiparametric flow cytometry immunophenotyping [126], live cells to develop bone marrow stromal cultures, and cryobanking. This enables our interdisciplinary group to obtain primary bone stromal and immune cells for immunophenotyping and expansion of ex vivo stromal cultures.…”

Section: Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment

Sethakorn

Héninger

Sánchez-de-Diego

et al. 2022

Cancers

Self Cite

View full text Add to dashboard Cite

Bone metastases represent a lethal condition that frequently occurs in solid tumors such as prostate, breast, lung, and renal cell carcinomas, and increase the risk of skeletal-related events (SREs) including pain, pathologic fractures, and spinal cord compression. This unique metastatic niche consists of a multicellular complex that cancer cells co-opt to engender bone remodeling, immune suppression, and stromal-mediated therapeutic resistance. This review comprehensively discusses clinical challenges of bone metastases, novel preclinical models of the bone and bone marrow microenviroment, and crucial signaling pathways active in bone homeostasis and metastatic niche. These studies establish the context to summarize the current state of investigational agents targeting BM, and approaches to improve BM-targeting therapies. Finally, we discuss opportunities to advance research in bone and bone marrow microenvironments by increasing complexity of humanized preclinical models and fostering interdisciplinary collaborations to translational research in this challenging metastatic niche.

show abstract

Section: Complex Multicellular Composition Of Bone and Bone Marrow Metastatic Nichesmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment

Sethakorn

Héninger

Sánchez-de-Diego

et al. 2022

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer

Cited by 1 publication

References 48 publications

Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment

Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment

Contact Info

Product

Resources

About