Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Sánchez, Jorge; Gonçalves, Eléna; Llano, Anuska; Gonzáles, Pedro; Fernández-Maldonado, María; Vogt, Annika; Soria, Angèle; Pérez, Susana Cedrés; Cedeño, Samandhy; Fernández, Marco A.; Nourikyan, Julien; Bernard, Simon; Ganoza, Carmela; Pédruzzi, Eric; Bonduelle, Olivia; Mothe, Beatriz; Gómez, Carmen Elena; Esteban, Mariano; García, Felipe; Lama, Javier R.; Berthou, Christian; Combadière, Béhazine

doi:10.3389/fimmu.2020.586124

Cited by 7 publications

(12 citation statements)

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“…The predominant microbial families relatively abundant in skin samples were Moraxellaceae, Staphylococcaceae and Pseudomonadaceae, whereas Ruminococcaceae, Lachnospiraceae, Prevotellaceae, and Bacteroidaceae were predominant in stool samples (Figures 1B, C). The 16S RNA sequencing generated several metrics: richness The amplitude of the humoral response was defined by the MVA-specific IgG neutralizing antibodies measured in serum at w8 post-vaccination (35). We observed no correlation between the MVA-Nab response and the baseline indexes of diversity and richness in either skin or stool (data not shown).…”

Section: Study Of Host Microbiota Before Vaccination and Relation To Post-vaccination Humoral Responsesmentioning

confidence: 90%

“…The CUTHIVAC-003 phase Ib randomized clinical study enrolled 20 volunteers aged 18–45 years at low risk of HIV infection, from October 15, 2014, to November 19, 2015 ( 35 ). The participants received HIV-1 MVA Clade B vaccine by either t.c.…”

Section: Methodsmentioning

confidence: 99%

“…or i.m. administration (1:1 ratio) after randomization for allocation at the Clinical trial unit (CTU) of the Asociacion Civil Impacta Salud y Educacion (IMPACTA) in Peru ( 35 ). The volunteers received vaccine on week (w) 0 by the allocated route of administration to assess its safety and immunogenicity against the MVA vector alone and against MVA-B.…”

Section: Methodsmentioning

confidence: 99%

“…The objective was to examine their potential involvement in an effective MVA-B neutralizing antibody (Nabs) response during the CUTHIVAC 03 randomized phase Ib clinical study. As published in a previous work ( 35 ), CUTHIVAC 03 clinical study included 10 HIV seronegative subjects aged from 18 to 45 years by the intramuscular route with MVA-HIV clade B vaccine. We analyzed their baseline transcriptomic signature and baseline bacterial species abundance and diversity in skin and stool to assess their potential association with the intensity of the Nabs response.…”

Section: Introductionmentioning

confidence: 99%

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Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

et al. 2021

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The identification of new biomarkers is essential to predict responsiveness to vaccines. We investigated the whole-blood transcriptome and microbiome prior to immunization, in order to assess their involvement in induction of humoral responses two months later. We based our analyses on stool and skin microbiota, and blood transcriptome prior to immunization, in a randomized clinical study in which participants were vaccinated with the MVA-HIV clade B vaccine (MVA-B). We found that the levels of neutralizing antibody responses were correlated with abundance of Eubacterium in stool and Prevotella in skin. In addition, genus diversity and bacterial species abundance were also correlated with the expression of genes involved in B cell development prior to immunization and forecast strong responders to MVA-B. To our knowledge, this is the first study integrating host blood gene expression and microbiota that might open an avenue of research in this field and to optimize vaccination strategies and predict responsiveness to vaccines.

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Section: Study Of Host Microbiota Before Vaccination and Relation To Post-vaccination Humoral Responsesmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

et al. 2021

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“…[ 45 ] In accordance with those investigations, immune profiling of individuals vaccinated with a vaccine based on Modified Vaccina Ankara virus, a vector previously shown to enter the hair follicle epithelium in mice, [ 31 ] revealed that this same transcutaneous vaccination procedure induced IL‐17 in the serum which was concomitant with CD8‐type responses assessed at day 28 after vaccination. [ 46 ]…”

Section: Introductionmentioning

confidence: 99%

A niche in the spotlight: Could external factors critically disturb hair follicle homeostasis and contribute to inflammatory hair follicle diseases?

Vogt

Constantinou

Rancan

et al. 2020

Experimental Dermatology

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Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery

Tuchin

Genina

Tuchina

et al. 2022

Advanced Drug Delivery Reviews

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Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Cited by 7 publications

References 50 publications

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

Host Transcriptome and Microbiota Signatures Prior to Immunization Profile Vaccine Humoral Responsiveness

A niche in the spotlight: Could external factors critically disturb hair follicle homeostasis and contribute to inflammatory hair follicle diseases?

Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery

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