Immune processes in vitamin deficiency states

Immune System in Uremia

“…Evidence that vitamin Be deficiency causes disturbances in cellular and humoral immunity has emerged from several studies [1][2][3]6,12,18,41], Restoration of vitamin Be in uremics resulted in the partial recovery of lymphocyte reactivity [11].…”

Vitamin B6 supplementation increases immune responses in critically ill patients

“…Although the mechanism of plasma pyridoxal 5 0 phosphate (PLP), the physiological active coenzyme form of vitamin B 6 , on immune responses has not yet been ascertained, the deficiency of PLP has been demonstrated to significantly impair both humoral and cell-mediated immunity (Kumar and Axelrod, 1968;Axlerod, 1971;Sergeev et al, 1978;Willis-Carr and St Pierre, 1978;Ha et al, 1984). Casciato et al (1984) indicated that eight hemodialysis patients supplemented with 50 mg/day of vitamin B 6 (pyridoxine hydrochloride (HCl)) for 3-5 weeks showed an improvement in their nitroblue tetrazolium reduction test, the generation of chemotactic factors from plasma, lymphocyte subpopulation and lymphocyte transformation in response to mitogens.…”

Immunologic Abnormalities in Hemodialysis Patients: Improvement after Pyridoxine Therapy

“…Pyridoxine deficiency per se may affect certain para meters of immune function, such as graft rejection and antibody responses [3][4][5][6][7], and many dialysis patients and patients with CRF are deficient in pyridoxine (vitamin B6). The effect of repletion of pyridoxine on tests of immune function, however, has not been extensively studied in these patients [8][9][10], We studied 8 chronic hemodialysis patients before and after 1 month of supplementation with pyridoxine.…”