Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Gregory J. Golden,
Vincent H. Wu,
Jacob T. Hamilton
et al.
Abstract:Autoimmune destruction of pancreatic β cells results in type 1 diabetes (T1D), with pancreatic immune infiltrate representing a key feature in this process. Studies of human T1D immunobiology have predominantly focused on circulating immune cells in the blood, while mouse models suggest diabetogenic lymphocytes primarily reside in pancreas-draining lymph nodes (pLN). A comprehensive study of immune cells in human T1D was conducted using pancreas draining lymphatic tissues, including pLN and mesenteric lymph no… Show more
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