J. Neurosci. Res. volume 86, issue 9, P1936-1943 2008 DOI: 10.1002/jnr.21652 View full text
Makoto Ideguchi, Mizuya Shinoyama, Masanori Gomi, Hideki Hayashi, Nobuo Hashimoto, Jun Takahashi

Abstract: Embryonic stem (ES) cells are a promising donor source for transplantation therapy, but several problems must be solved before they can be clinically useful. One of these is the host immune reaction to allogeneic grafts. In this article, we examine the effect of the host immune reaction on survival and differentiation of grafted ES cell-derived neural precursor cells (NPCs). We induced NPCs from mouse ES cells by stromal cell-derived inducing activity and then transplanted them into mouse brains with or withou…

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