Immune monitoring of the body’s borders

Rosenthal, Ken S.

doi:10.3934/allergy.2018.3.148

Cited by 1 publication

(1 citation statement)

References 74 publications

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“…This is especially true for the immune system which maintains a balance between the status quo (maintenance of homeostasis) and activation of effector and inflammatory responses. 1,2 Challenges from trauma, infections, neoplasms, and autoimmunity disrupt the normal balance by promoting a cycle of immune/inflammatory responses that continue as long as there are stimuli (tissue disruption, pathogenic microbes, antigens) and drivers (effector cells and molecules e.g. cytokines, chemokines, antibodies).…”

Section: Introductionmentioning

confidence: 99%

Vaccine Immunomodulation of Disease: Targeting the Treatment of Autoimmune Diseases

Rosenthal¹,

Zimmerman

2022

MRAJ

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Autoimmune disease disrupts the normal immunological balance by promoting a perpetual cycle of innate/immune/inflammatory responses that continues due to the continued presence of antigen. The disease cycle is in turn amplified and regulated by cycles of antigen-specific T cell mediated immune responses. Removal of the stimuli or regulation of the disease drivers can stop the cycle to allow rebalancing and prevent the progression or chronicity of disease. As an alternative to the current treatments for autoimmune and inflammatory disease, which reduce, inhibit or eliminate the triggers, drivers or antigens, newer approaches stimulate regulatory responses, or inhibit or repurpose the effector/inflammatory responses to control the immune disease cycle. LEAPS (Ligand Epitope Antigen Presentation System) therapeutic vaccines for rheumatoid arthritis are presented as examples of therapies that elicit antigen specific T cell modulation of autoimmune and inflammatory responses to treat disease.

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Section: Introductionmentioning

confidence: 99%