Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats

Kara, Adem; Akman, Sumeyra; Özkanlar, Seçkin; Tozoğlu, Ümmühan; Kalkan, Yıldıray; Çanakçı, Cenk Fatih; Tozoglu, Sinan

doi:10.1016/j.freeradbiomed.2012.11.002

Cited by 95 publications

(122 citation statements)

References 42 publications

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“…However, the results were not significant. It is thought that melatonin reduces the alveolar bone loss by affecting the inflammatory host response (20).…”

Section: Discussionmentioning

confidence: 99%

“…Physiological and pharmacological doses of melatonin increase enzyme activity and the gene expression of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (14). It also has a direct neutralizing effect on ROS (19) and MDA (14,20). Melatonin may also contribute to the antioxidative defence by directly affecting free radicals or indirectly preventing production of ROS (14,21).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

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“…However, the results were not significant. It is thought that melatonin reduces the alveolar bone loss by affecting the inflammatory host response (20).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

View full text Add to dashboard Cite

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“…β-carotene and chlorophyll are among the most important antioxidants in the living organisms. Stressful situations can increase the yield of their production as a prophylactic mechanism to overcome destructive effects of ROS and free radicals (Kara et al, 2013). Monoterpenes piperitone and menthone can increase the production of β-carotene and chlorophyll by induction of stress to the microalgae cells, which could be useful to improve the carotenoid production.…”

Section: Resultsmentioning

confidence: 99%

Effects of menthone and piperitone on growth, chlorophyll a and beta-carotene production in Dunaliella salina

Zarei¹,

Mobasher²,

Morowvat³

et al. 2016

J App Pharm Sci

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Recently, studying essential oils and secondary metabolites of plants and microalgae have received much attention. The biosynthesis of the secondary metabolites is strongly influenced by different environmental factors. Monoterpenes as a main fraction of essential oils of fruits and vegetables have many clinical applications. They could inhibit the carcinogenesis processes and therefore might be effective in treatment of cancers. Dunaliella salina, a photosynthetic green microalga is known as a rich source for β-carotene production. In this study, the effects of some monoterpenes including menthone and piperitone was investigated on yield of production of β-carotene were studied. Menthone and piperitone as parameters of stress can make tensions to the medium of D. salina increasing its β-carotene and chlorophyll a content in every single cell but on the other hand these two monoterpenes cause a decrease in the concentration of β-carotene and chlorophyll a.

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“…Melatonin has also proven to be an effective treatment for oral infections such as herpes [74]. Kara et al showed that it decreases proinflammatory cytokines in gingivitis and periodontitis [77]. Cutando et al [78] showed that melatonin treatment in patients with diabetes significantly reduced the gingival index, pocket depth and RANKL levels and also increased osteoprotegrin concentrations.…”

Section: A) Melatonin In the Oral Cavitymentioning

confidence: 99%

Oral Mucositis: Melatonin Gel an Effective New Treatment

Moneim¹,

Guerra‐Librero²,

Florido³

et al. 2017

Preprint

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Abstract:The current treatment for cervico-facial cancer involves radio and/or chemotherapy.Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract.Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, melatonin, whose role in the treatment of mucositis has recently been investigated, offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients' lives.Keywords: mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin Overview of mucositis pathobiologyMucositis, one of the most severe toxic side effects of cancer therapy, can affect the entire gastrointestinal tract, with the oral cavity being the most common affected site. It presents in virtually all head and neck cancer patients receiving chemo and/or radiotherapy, in 60-85% of those receiving myeloablative therapy for stem-cell transplantation and in 20-40% of patients receiving conventional chemotherapy [1][2][3]. The use of concomitant chemotherapy and/or targeted agents increases the risk of mucositis.Oral lesions lead to considerably decreased quality of life in these patients due to solid and liquid food dysphagia, dysarthria and odynophagia, resulting in depression in some patients, who often require percutaneous endoscopic gastrostomy tube insertion [4]. In addition, mucositis lesions may represent a gateway to opportunistic infections, can complicate cancer treatment and extend hospitalization [5][6]. On the other hand, given its dose-limiting toxicity for both chemo and radiotherapy, mucositis can have a direct impact on survival rates [7]. Pathophysiology of mucositisRecent developments in mucositis research have highlighted multiple factors which contribute to mucosal injury [8]. A five-phase chronological process has been proposed: initiation, primary damage response (upregulation and message generation), signal amplification, ulceration and the healing phase [9]. Mucositis commences when gastrointestinal (GI) mucosa are exposed to cytotoxic agents, resulting in cellular DNA damage and cell death, mainly through the generation of oxidative Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 9 March 2017 doi:10.20944/preprints201703.0052.v1Peer-reviewed version available at Int. J. Mol. Sci. 2017, 18, , 1003 doi:10.3390 The progression of mucositis is characterized by significant inflammatory mediator up-regulation due to the activation of the NF-κB pathway (upregulation and message generation phase). This is followed by the signaling and amplification phase, during which, once activated by chemotherapy and ROS, NF-κB promotes the expression of multiple pro-inflammatory molecules, including inducible nitric oxid...

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Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats

Cited by 95 publications

References 42 publications

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Effects of menthone and piperitone on growth, chlorophyll a and beta-carotene production in Dunaliella salina

Oral Mucositis: Melatonin Gel an Effective New Treatment

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