Immune modulations and survival strategies of evolved hypervirulent Salmonella Typhimurium strains

Pradhan, D.; Pradhan, Jasmin; Mishra, Abtar; Karmakar, Kapudeep; Dhiman, Rohan; Chakravortty, Dipshikha; Negi, Vidya Devi

doi:10.1016/j.bbagen.2020.129627

Cited by 3 publications

(1 citation statement)

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“…Although gastroenteritis is a localized infection of the intestinal mucosa and mesenteric lymph nodes, the enhanced production of pro-inflammatory cytokines induces acute inflammation and is required for Salmonella clearance (Pradhan et al, 2020). We speculated that the effect of spvC on suppressing IL-1β secretion and attenuating host defense may lead to S. Typhimurium dissemination.…”

Section: Discussionmentioning

confidence: 99%

Salmonella spvC Gene Inhibits Pyroptosis and Intestinal Inflammation to Aggravate Systemic Infection in Mice

Zuo

Zhou

et al. 2020

Front. Microbiol.

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Salmonella enterica serovar Typhimurium (S). Typhimurium is a primary foodborne pathogen infecting both humans and animals. Salmonella plasmid virulence C (spvC) gene is closely related to S. Typhimurium dissemination in mice, while the mechanisms remain to be fully elucidated. Pyroptosis, a gasdermin-mediated inflammatory cell death, plays a role in host defense against bacterial infection, whereas the effect of spvC on pyroptosis and its function in inflammatory injury induced by S. Typhimurium are rather limited. In our study, C57BL/6 mice and J774A.1 cells infected with S. Typhimurium wild-type strain SL1344, spvC deletion mutant, spvC K136A site-directed mutant, and complemented strain were used to investigate potential pathogenesis of spvC. We verity that SpvC attenuates intestinal inflammation, suppresses pyroptosis through phosphothreonine lyase activity, and reduces pyroptosis in the ceca. Moreover, the reduction of inflammation via spvC results in systemic infection. These findings demonstrate that spvC inhibits pyroptosis and intestinal inflammation to promote bacterial dissemination, which provide new strategies for controlling systemic infection caused by Salmonella and novel insights for the treatment of other corresponding diseases.

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Section: Discussionmentioning

confidence: 99%