Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory
Ayesha B. Alvero,
Alexandra Fox,
Bhaskara Madina
et al.
Abstract:Current immunotherapies have proven effective in strengthening anti-tumor immune responses but constant opposing signals from tumor cells and surrounding microenvironment eventually lead to immune escape. We hypothesize that in situ release of antigens and regulation of both the innate and adaptive arms of the immune system will provide a robust and long-term anti-tumor effect by creating immunological memory against the tumor. To achieve this, we developed CARG-2020, a virus-like-vesicle (VLV). It is a geneti… Show more
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