Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Leonard Knoedler,
Jillian Dean,
Fortunay Diatta
et al.
Abstract:Balancing the immune response after solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) remains an ongoing clinical challenge. While immunosuppressants can effectively reduce acute rejection rates following transplant surgery, some patients still experience recurrent acute rejection episodes, which in turn may progress to chronic rejection. Furthermore, these immunosuppressive regimens are associated with an increased risk of malignancies and metabolic disorders. Despite sign… Show more
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