Immune Modulation in Response to Stress and Relaxation

Mahbub-E-Sobhani,; Haque, Nazmul; Salma, Umme; Ahmed, Amna

doi:10.3923/pjbs.2011.363.374

Cited by 18 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies have sought to alleviate the immune dysregulation brought about by stress by means of different relaxation techniques (e.g., relaxation or calming responses, progressive muscle relaxation, biofeedback-assisted relaxation) [38–41]. Mahbub-E-Sobhani et al [42], in their review of immune modulation in response to stress and relaxation, concluded that there is a variety of stressors that have a negative impact on immune function (for instance, by secreting glycocorticoids), but that approaches akin to relaxation techniques could help maintain homeostasis by secreting β-endorphins that trigger an increase in NK cells and, thus, enhance immunity.…”

Section: Discussionmentioning

confidence: 99%

A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: A randomized controlled study

Reig-Ferrer

Ferrer‐Cascales

Santos-Ruiz

et al. 2014

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe aging process involves a decline in immune functioning that renders elderly people more vulnerable to disease. In residential programs for the aged, it is vital to diminish their risk of disease, promote their independence, and augment their psychological well-being and quality of life.MethodsWe performed a randomized controlled study, evaluating the ability of a relaxation technique based on Benson’s relaxation response to enhance psychological well-being and modulate the immune parameters of elderly people living in a geriatric residence when compared to a waitlist control group. The study included a 2-week intervention period and a 3-month follow-up period. The main outcome variables were psychological well-being and quality of life, biomedical variables, immune changes from the pre-treatment to post-treatment and follow-up periods.ResultsOur findings reveal significant differences between the experimental and control groups in CD19, CD71, CD97, CD134, and CD137 lymphocyte subpopulations at the end of treatment. Furthermore, there was a decrease in negative affect, psychological discomfort, and symptom perception in the treatment group, which increased participants’ quality of life scores at the three-month follow-up.ConclusionsThis study represents a first approach to the application of a passive relaxation technique in residential programs for the elderly. The method appears to be effective in enhancing psychological well-being and modulating immune activity in a group of elderly people. This relaxation technique could be considered an option for achieving health benefits with a low cost for residential programs, but further studies using this technique in larger samples of older people are needed to confirm the trends observed in the present study.Trial registrationInternational Standard Randomised Controlled Trial Number Register ISRCTN85410212

show abstract

Section: Discussionmentioning

confidence: 99%

A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: A randomized controlled study

Reig-Ferrer

Ferrer‐Cascales

Santos-Ruiz

et al. 2014

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…From an immune point of view, chronic stress can alter immune balance and may be responsible for increasing prevalence and worse severity of asthma, at least partially [13, 14]. Psychological stress is also linked to neuro-endocrino-immune network in asthma [15]. Accordingly, asthma is regarded primarily as a psychological disease and psychological stress is considered to exert impact on neuroendocrine-immune modulation, thus influenced the progression of asthma.…”

Section: Introductionmentioning

confidence: 99%

Participation of Antidiuretic Hormone (ADH) in Asthma Exacerbations Induced by Psychological Stress via PKA/PKC Signal Pathway in Airway-Related Vagal Preganglionic Neurons (AVPNs)

Hou¹,

Zhu²,

Zhang³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Aims: Present study was performed to examine whether ADH was implicated in psychological stress asthma and to explore the underlying molecular mechanism. Methods: We not only examined ADH levels in the cerebrospinal fluid (CSF) via radioimmunoassay, but also measured ADH receptor (ADHR) expression in airway-related vagal preganglionic neurons (AVPNs) through real-time PCR in all experimental mice. Western blotting was performed to evaluate the relationship between ADH and PKA/PKC in psychological stress asthma. Finally, the role of PKA/PKC in psychological stress asthma was analyzed. Results: Marked asthma exacerbations were noted owing to significantly elevated levels of ADH and ADHR after psychological stress induction as compared to OVA alone (asthma group). ADHR antagonists (SR-49095 or SR-121463A) dramatically lowered higher protein levels of PKAα and PKCα induced by psychological stress as compared to OVA alone, suggesting the correlation between ADH and PKA/PKC in psychological stress asthma. KT-5720 (PKA inhibitor) and Go-7874 (PKC inhibitor) further directly revealed the involvement of PKA/PKC in psychological stress asthma. Some notable changes were also noted after employing PKA and PKC inhibitors in psychological stress asthma, including reduced asthmatic inflammation (lower eosinophil peroxidase (EPO) activity, myeloperoxidase (MPO) activity, immunoglobulin E (IgE) level, and histamine release), substantial decrements in inflammatory cell counts (eosinophils and lymphocytes), and decreased cytokine secretion (IL-6, IL-10, and IFN-γ), indicating the involvement of PKA/PKC in asthma exacerbations induced by psychological stress. Conclusion: Our results strongly suggested that ADH participated in psychological stress-induced asthma exacerbations via PKA/PKC signal pathway in AVPNs.

show abstract

Potentially Traumatic Events and the Risk of Six Physical Health Conditions in a Population-Based Sample

et al. 2013

View full text Add to dashboard Cite

Background Potentially traumatic events (PTEs) are common in the population, yet, the impact of total burden and specific types of PTEs on physical health has not been systematically investigated. Methods Data were drawn from the Detroit Neighborhood Health Study, a community sample of predominately African Americans living in Detroit, Michigan, interviewed in 2008–2009 (N = 1,547) and in 2009–2010 (N = 1,054). Kaplan–Meier and Cox proportional hazards models were used. Results Respondents with the highest levels of PTE exposure (8+ events) had an average age of adverse physical health condition diagnosis that was 15 years earlier than respondents with no exposure. There was a monotonic relation between number of PTEs and arthritis risk. Compared to those who reported no lifetime events, respondents with 1–2, 3–4, 5–7, and 8+ traumatic events had 1.06, 1.12, 1.73, and 2.44 times the hazard of arthritis. Assaultive violence (HR = 1.7; 95% CI 1.2–2.3) and other threats to physical integrity (HR = 1.5, 95% CI 1.1–2.1) were particularly strong risk factors for arthritis. Conclusions These results provide novel evidence linking PTEs, particularly those involving violence and threat to life, to elevated risk for arthritic conditions. Efforts to prevent or mitigate traumatic event exposures may have a broad range of benefits for health.

show abstract

Immune Modulation in Response to Stress and Relaxation

Cited by 18 publications

References 18 publications

A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: A randomized controlled study

A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: A randomized controlled study

Participation of Antidiuretic Hormone (ADH) in Asthma Exacerbations Induced by Psychological Stress via PKA/PKC Signal Pathway in Airway-Related Vagal Preganglionic Neurons (AVPNs)

Potentially Traumatic Events and the Risk of Six Physical Health Conditions in a Population-Based Sample

Contact Info

Product

Resources

About