Immune modulation in acute and chronic pancreatitis

Habtezion, Aida

doi:10.3998/panc.2016.30

Cited by 3 publications

(1 citation statement)

References 104 publications

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“…Various anti-inflammatory agents, such as Sivelestat, Glycyrrhizine, Rofecoxib, Flavocoxid and Lisinopril, have been studied in AP therapy (Figure 3). The detailed mechanisms of action targeting both the innate and adaptive immune arms by these agents in AP have been discussed elsewhere [99]. Among different anti-inflammatory agents, IL-6 inhibitors have showed promise towards AP therapy.…”

Section: Impact Of Targeting the Adaptive Immune Arm In Pancreatitismentioning

confidence: 99%

Alcohol and Smoking Mediated Modulations in Adaptive Immunity in Pancreatitis

Bhatia

Thompson

Ganguly

et al. 2020

Cells

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Pancreatitis is a condition of pancreatic inflammation driven by injury to the pancreatic parenchyma. The extent of acinar insult, intensity, and type of immune response determines the severity of the disease. Smoking, alcohol and autoimmune pancreatitis are some of the predominant risk factors that increase the risk of pancreatitis by differentially influencing the adaptive immune system. The overall decrease in peripheral lymphocyte (T-, B- and (natural killer T-) NKT-cell) count and increased infiltration into the damaged pancreatic tissue highlight the contribution of adaptive immunity in the disease pathology. Smoking and alcohol modulate the responsiveness and apoptosis of T- and B-cells during pancreatic insult. Acute pancreatitis worsens with smoking and alcohol, leading to the development of systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome, suggesting the critical role of adaptive immunity in fatal outcomes such as multiple organ dysfunction. The presence of CD4+ and CD8+ T-lymphocytes and perforin-expressing cells in the fibrotic tissue in chronic pancreatitis modulate the severity of the disease. Due to their important role in altering the severity of the disease, attempts to target adaptive immune mediators will be critical for the development of novel therapeutic interventions.

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Section: Impact Of Targeting the Adaptive Immune Arm In Pancreatitismentioning

confidence: 99%

Alcohol and Smoking Mediated Modulations in Adaptive Immunity in Pancreatitis

Bhatia

Thompson

Ganguly

et al. 2020

Cells

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Adaptive Immune Cell Dysregulation and Role in Acute Pancreatitis Disease Progression and Treatment

Fonteh

Brand

2017

Arch. Immunol. Ther. Exp.

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Acute pancreatitis (AP) is an inflammation of the pancreas caused by various stimuli including excessive alcohol consumption, gallstone disease and certain viral infections. Managing specifically the severe form of AP is limited due to lack of an understanding of the complex immune events that occur during AP involving immune cells and inflammatory molecules such as cytokines. The relative abundance of various immune cells resulting from the immune dysregulation drives disease progression. In this review, we examine the literature on the adaptive immune cells in AP, the prognostic value of these cells in stratifying patients into appropriate care and treatment strategies based on cell frequency in different AP severities are discussed.

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