Immune modulation effects of curcumin in pristane-induced lupus mice

Kalim, Handono; Handono, Kusworini; Khalasha, Takhta; Pratama, Mirza Zaka; Dantara, Tri Wahyudi Iman; Wulandari, Ayu Pramitha; Albinsaid, Fahimma; Fitria, Sofi Nur; Mahardika, Muhammad Vardian

doi:10.4103/injr.injr_95_16

Cited by 10 publications

(12 citation statements)

References 2 publications

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“…20 The results showed that pristane induced immunity disregulation and induced autoreactive of B cells shown by producing autoantibodies like ANA. 19,21 ANA serum titersare increased in the week 16.…”

Section: Discussionmentioning

confidence: 98%

“…These results supported our previous study that manifestations of SLE such as arthritis, alopecia, and ascites appear in BALB/c mice model after single dose of 0.5 mg pristane injection intraperitonealy. 19 Based on the kinetics of autoantibody development following exposure to pristane, 16 weeks of the first clinical manifestation period was chosen. 20 The results showed that pristane induced immunity disregulation and induced autoreactive of B cells shown by producing autoantibodies like ANA.…”

Section: Discussionmentioning

confidence: 99%

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<em>Bryophyllum pinnatum</em> leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells

et al. 2018

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Background: B cells play a key role in systemic lupus erythematosus (SLE). Targeting B cells as SLE therapy is a plausible approach. This study investigated the potential effects of Bryophyllum pinnatum leaves with ethanol extract in decreasing percentages of maturation, increasing percentages of apoptosis, and decreasing NF-κB p65 expressions of SLE BALB/c mice B cells.Methods: Culturing B cells from pristane induced SLE BALB/c mice’s spleen will resulted in this in vitro study. B cells were activated by BAFF, LPS, IL-4, and anti-CD40 yielding CD19+ >80%. B cells were cultured by adding those stimulants with and without B. pinnatum leaves (0, 0.02, 0.1, or 0.5 µg/ml) for 72 hours at 37°C. Flow cytometry was performed to determine The Percentages of maturation (CD19+CD38+) and apoptosis (Annexin V+PI+) of B cells. Further analysis to determine the expressions of transcription factor of maturation and apoptosis of B cells, NF-ĸB p65, were performed using immunocytochemistry. Data were analyzed using SPSS version 22.Results: Flow cytometry assay showed significant decrease in percentages of maturation of B cells in all doses and significant increase in percentage of apoptosis of B cells in dose 0.5 µg/ml. Immunocytochemistry results showed significant decrease expressions of NF-ĸB p65 in all doses. Percentages of maturation, apoptosis, and expressions of NF-ĸB p65 of B cells were significantly correlated.Conclusion: This in vitro study revealed that B. pinnatum leaves with ethanol extract decreased the percentages of maturation, increased the percentage of apoptosis, and decreased NF-κB p65 expressions of SLE BALB/c mice B cells significantly.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

<em>Bryophyllum pinnatum</em> leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells

et al. 2018

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“…Various studies have reported that curcumin can precisely modify the Th17/Treg balance on CD4 + T-cells and attenuate organ damage in SLE subjects (Handono et al, 2015). Kalim et al also found a reduction in Th17 and an improvement in Treg cells following 200 mg kg day À1 of curcumin dosing in an SLE mouse model (Kalim et al, 2017). Vitamin D has key molecular functions in immune system regulation in individuals affected with SLE.…”

Section: Curcumin and Juvenile Idiopathic Arthritismentioning

confidence: 99%

“…Vitamin D has key molecular functions in immune system regulation in individuals affected with SLE. In SLE patients with low vitamin D levels, the combination of vitamin D and curcumin can decrease the serum concentration of anti-dsDNA and proteinuria compared to the combination of vitamin D and placebo (Kalim et al, 2017). In contrast, some reported data have suggested that curcumin may augment proinflammatory properties in SLE and that curcumin treatment (50 mg kg day À1 in sesame oil; i.p.…”

Section: Curcumin and Juvenile Idiopathic Arthritismentioning

confidence: 99%

Immunomodulatory effects of curcumin in systemic autoimmune diseases

Chamani

Moossavi

Naghizadeh

et al. 2022

Phytotherapy Research

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Systemic autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus represent various autoimmune conditions identified by immune system dysregulation. The activation of immune cells, auto-antigen outbreak, inflammation, and multi-organ impairment is observed in these disorders. The immune system is an essential complex network of cells and chemical mediators which defends the organism's integrity against foreign microorganisms, and its precise operation and stability are compulsory to avoid a wide range of medical complications. Curcumin is a phenolic ingredient extracted from turmeric and belongs to the Zingiberaceae, or ginger family. Curcumin has multiple functions, such as inhibiting inflammation, oxidative stress, tumor cell proliferation, cell death, and infection. Nevertheless, the immunomodulatory influence of curcumin on immunological reactions/processes remains mostly unknown. In the present narrative review, we sought to provide current information concerning the preclinical and clinical uses of curcumin in systemic autoimmune diseases.

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“…Administration of curcumin to pristaneinduced lupus mice decreased Th1, Th2, and Th17 and slightly increased Treg percentages. In addition, ANA levels were also decreased after curcumin treatment (Kalim et al, 2017). Curcumin was able to enhance immune response in Macrobrachium rosenbergii after being challenged with Vibrio alginolyticus (Alambra et al, 2012).…”

Section: In Vivo Immunomodulating Effect Of Curcuminmentioning

confidence: 99%

Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review

et al. 2021

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Curcuma species (family: Zingiberaceae) are widely utilized in traditional medicine to treat diverse immune-related disorders. There have been many scientific studies on their immunomodulating effects to support their ethnopharmacological uses. In this review, the efficacy of six Curcuma species, namely, C. longa L., C. zanthorrhiza Roxb., C. mangga Valeton & Zijp, C. aeruginosa Roxb. C. zedoaria (Christm.) Roscoe, and C. amada Roxb., and their bioactive metabolites to modulate the immune system, their mechanistic effects, and their potential to be developed into effective and safe immunomodulatory agents are highlighted. Literature search has been carried out extensively to gather significant findings on immunomodulating activities of these plants. The immunomodulatory effects of Curcuma species were critically analyzed, and future research strategies and appropriate perspectives on the plants as source of new immunomodulators were discussed. Most of the pharmacological investigations to evaluate their immunomodulatory effects were in vivo and in vitro experiments on the crude extracts of the plants. The extracts were not chemically characterized or standardized. Of all the Curcuma species investigated, the immunomodulatory effects of C. longa were the most studied. Most of the bioactive metabolites responsible for the immunomodulating activities were not determined, and mechanistic studies to understand the underlying mechanisms were scanty. There are limited clinical studies to confirm their efficacy in human. Of all the bioactive metabolites, only curcumin is undergoing extensive clinical trials based on its anti-inflammatory properties and main use as an adjuvant for the treatment of cancer. More in-depth studies to understand the underlying mechanisms using experimental in vivo animal models of immune-related disorders and elaborate bioavailability, preclinical pharmacokinetics, and toxicity studies are required before clinical trials can be pursued for development into immunomodulatory agents.

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Immune modulation effects of curcumin in pristane-induced lupus mice

Cited by 10 publications

References 2 publications

<em>Bryophyllum pinnatum</em> leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells

<em>Bryophyllum pinnatum</em> leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells

Immunomodulatory effects of curcumin in systemic autoimmune diseases

Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review

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