Immune modulation by curcumin: The role of interleukin-10

Abstract

Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8 T cells, and T1, T2, and T17 and regulatory T cells. Both direct and indirect activation of the stress axis promotes IL-10 secretion. IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy. Curcumin is a natural anti-inflammatory compound able to induce the expression and production of IL-10 and enhancing its action on a large number of tissues. In vitro and in pre-clinical models curcumin is able to modulate the disease pathophysiology of conditions such as pain and neurodegenerative diseases, bowel inflammation, and allergy, but also of infections and cancer through its effect on IL-10 secretion. In humans, at least one part of the positive effects of curcumin on health could be related to its ability to enhance IL-10 -mediated effects.

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

“…They inhibit the release of pro-inflammatory cytokines and activate anti-inflammatory cytokines' production [52]. However, curcumin has shown the ability to inhibit the production of TNF-α and some pro-inflammatory interleukins such as IL-1 and IL-6, while increasing the production of anti-inflammatory IL-10 [49,53,54]. In the current study, to investigate whether curcuminoids may influence pro-inflammatory or anti-inflammatory activation, SKOV-3 cells were cultured in a basal medium without an additional stimulation agent in the absence and presence of curcuminoids.…”

The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review

“…Curcumin is an active ingredient of turmeric spices (Curcuma longa L.) and has been used as a food spice and herbal remedy for centuries in different traditional medicine systems [95]. Because of its highly bioactive compounds it has been reported to have several pharmacological effects including anti-inflammatory, antitumor, lipid-modifying, antioxidant, anti-steatotic, antifibrotic, cardioprotective and antithrombotic activities [96][97][98][99][100][101][102][103][104][105]. The anti-atherosclerotic and cardioprotective effects are thought to be mediated through reduced LDL-oxidation [106,107].…”

Effects of Plant and Animal Natural Products on Mitophagy

“…Curcumin is a naturally occurring phenolic compound obtained from Curcuma longa. Several curcumin-mediated pharmacological effects have been described, including antiinflammatory [36][37][38], immunomodulatory [39], antitumor and chemosensitizing [40][41][42], anti-ischemic [43], hepatoprotective [44], relaxant [45], and antiasthmatic effects [46,47]. Effects of curcumin (10 μM) on the viability of nasopharyngeal carcinoma CNE2 cells exposed to ultrasound were investigated by Wang et al In their study, ultrastructure of mitochondria was disrupted and mitophagy was induced by curcumin in CNE2 cells [48].…”