Immune microenvironment-reshaping Au@Bi2Te3 nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy

Zhu, Kai; Wu, Zede; Li, Qiuyu; Hou, Meirong; Hu, Hai; Zheng, Shuting; Li, Qi; Xu, Yikai; Yan, Changqing; Zhao, Bingxia

doi:10.1007/s12274-022-4645-3

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…916 Furthermore, PD-L1 expression of tumor cells could be upregulated by RT in individuals or mouse models. [917][918][919][920] Sang et al 921 employed a combinatory strategy with X-ray-mediated RT-RDT and ICB therapy to generate potent antitumor immune responses against primary tumors and metastases. The development of theranostic nanoplatforms, specifically referred to as Hb@Hf-Ce6 NPs, had the potential to sensitize RT and transport oxygen, thereby considerably overcoming RT resistance, improving RT-RDT efficacy, and modulating hypoxic TME to reverse immunosuppression.…”

Section: Nps For Radioimmunotherapymentioning

confidence: 99%

“…On the one hand, clinical research had demonstrated that RT can be beneficial for ICB therapy because it can potentially affect the antitumor immune cycle 916 . Furthermore, PD‐L1 expression of tumor cells could be upregulated by RT in individuals or mouse models 917–920 . Sang et al 921 employed a combinatory strategy with X‐ray‐mediated RT‐RDT and ICB therapy to generate potent antitumor immune responses against primary tumors and metastases.…”

Section: Cancer Therapies Using Npsmentioning

confidence: 99%

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Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Nps For Radioimmunotherapymentioning

confidence: 99%

Section: Cancer Therapies Using Npsmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…Therefore, ideal RT efficiency on breast cancer by the composites was realized as proved by the H&E and Ki67 staining of tumor post treatment (Figure 12c(ii)). [246] To enhance the activity of the CAT-like nanozymes trapped in endosomes (pH 5.5) and lysosomes (pH 4.8), Au NCs decorated by amine-terminated PAMAM dendrimer with constantly high CAT-like activity among pH 4.8-7.4 performed well in the PDT against lung cancer cells. [174] In addition, the as-mentioned hollow CeO 2 nanozymes with the acidic preferred CAT-like activity were proved to be ideal PDT agents that target the lysosome of breast cancer cells.…”

Section: Antitumormentioning

confidence: 99%

Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Feng,

Wang,

Wang

et al. 2024

Advanced Materials

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Although nanozymes have drawn a great attention over the past decade, the activities of peroxidase‐like, oxidase‐like and catalase‐like nanozymes are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on the pH related catalytic mechanisms of nanozymes together with the methods to overcome this limitation is in need. In this review, various nanozymes exhibiting pH dependent catalytic activities are collected and the root causes for their pH dependence are comprehensively analyzed. Subsequently, regulatory concepts including catalytic environment reconstruction and direct catalytic activity improvement to break this pH restriction are summarized. Moreover, applications of pH independent nanozymes in sensing, disease therapy and pollutant degradation are overviewed. Finally, current challenges and future opportunities on the development of pH independent nanozymes are suggested. It is anticipated that this review will promote the further design of pH independent nanozymes and broaden their application range with higher efficiency.This article is protected by copyright. All rights reserved

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“…In addition, Zhu and Wu et al have devised a polyethylene glycol (PEG)-modified Au@Bi 2 Te 3 nanoenzyme to simultaneously alleviate tumoral hypoxia and combine mild PTT and RT to elicit ICD. [116] Among the Au@Bi 2 Te 3 -PEG nanoenzyme, the ultrasmall Bi 2 Te 3 nanodots possessed effective photothermal conversion capability and the outer gold shells provide CAT-like efficacy, which could specifically produce oxygen in the H 2 O 2overexpressed tumor site. The alleviated tumoral hypoxia not only enhanced the ROS generation under X-ray irradiation for better RT efficacy, but also reshaped the immunosuppressive TME to downregulate PD-L1 expression and recruits more effector T cells for potent immune response.…”

Section: Combined Ptt and Rt-induced Icdmentioning

confidence: 99%

Radiation‐Induced Immunogenic Cell Death for Cancer Radioimmunotherapy

Pei

Shen

et al. 2023

Small Methods

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In cancer treatment, traditional radiotherapy (RT) is routinely conducted in local tumors and limited by radioresistance, while recently emerged immunotherapy is confronted with low response rate, high cost, and cytokine release syndrome. Logically, the combination of the two therapeutic modalities into radioimmunotherapy is promising to complement with each other for systemic elimination of cancer cells with high specificity, efficiency, and safety. Especially, RT‐induced immunogenic cell death (ICD) plays an imperative role in radioimmunotherapy to evoke systemic immune response against cancer, including elevating the immunity of tumor antigens, recruiting and activating antigen‐presenting cells, and priming cytotoxic T lymphocytes for tumoral infiltration and cancer cell eradication. This review first retrospects the origin and concept of ICD, summarizes the major damage‐associated molecular patterns and signaling pathways, and highlights the characteristics of RT‐induced ICD. Subsequently, therapeutic strategies enhancing RT‐induced ICD for radioimmunotherapy are reviewed from the perspectives of enhancing RT itself, combination with other treatments, and stimulating the holistic immune system. On the basis of these published research and underlying mechanism, this work attempts to forecast possible directions for RT‐induced ICD enhancement to promote clinical applications.

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Immune microenvironment-reshaping Au@Bi2Te3 nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy

Cited by 6 publications

References 40 publications

Advances and applications of nanoparticles in cancer therapy

Advances and applications of nanoparticles in cancer therapy

Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Radiation‐Induced Immunogenic Cell Death for Cancer Radioimmunotherapy

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