Immune memory in invertebrates

Milutinović, Barbara; Kurtz, Joachim

doi:10.1016/j.smim.2016.05.004

Cited by 232 publications

(253 citation statements)

References 182 publications

Supporting

Mentioning

248

Contrasting

Order By: Relevance

“…But non-specificity and non-self may be out-dated concepts; innate immune systems have targeted responses and memory 2,3 , and many organisms are not discrete ‘self’ entities with borders to defend 4 . Corals are complex mutualisms among multicellular partners and associated microbiota, which influence coral physiology sensu latu 5,6 .…”

Section: Immunity Purveyor Of Healthmentioning

confidence: 99%

“…However, innate immune systems of organisms including plants and invertebrates also, arguably, demonstrate immune memory, which is sometimes called priming 3 . In contradiction of innate immune systems being non-specific, typically, immune memory is investigated as a primed response to a specific parasitic infection, which subsides between challenges and provides resistance upon re-infection.…”

Section: Immune Memory Acclimatization and Adaptationmentioning

confidence: 99%

“…In contradiction of innate immune systems being non-specific, typically, immune memory is investigated as a primed response to a specific parasitic infection, which subsides between challenges and provides resistance upon re-infection. Immune memory can also be an acquired resistance or sustained response that protects against a future challenge—an anticipatory response 3,78 . In addition to immune memory, innate immune systems, such as those of plants, display cross-tolerance, whereby responding to one perturbation increases tolerance or resistance to others 18 .…”

Section: Immune Memory Acclimatization and Adaptationmentioning

confidence: 99%

“…In addition to immune memory, innate immune systems, such as those of plants, display cross-tolerance, whereby responding to one perturbation increases tolerance or resistance to others 18 . Considering the coral holobiont immune system responds to both biotic and abiotic stimuli, immune memory with its heritability described for other invertebrates 3 , is a tantalizing topic in this era of climate change and coral reef crisis 79 .…”

Section: Immune Memory Acclimatization and Adaptationmentioning

confidence: 99%

See 3 more Smart Citations

Immunity and the coral crisis

Palmer

2018

Commun Biol

View full text Add to dashboard Cite

show abstract

Section: Immunity Purveyor Of Healthmentioning

confidence: 99%

Section: Immune Memory Acclimatization and Adaptationmentioning

confidence: 99%

Section: Immune Memory Acclimatization and Adaptationmentioning

confidence: 99%

Section: Immune Memory Acclimatization and Adaptationmentioning

confidence: 99%

See 2 more Smart Citations

Immunity and the coral crisis

Palmer

2018

Commun Biol

View full text Add to dashboard Cite

show abstract

“…Invertebrates, which lack the canonical adaptive immunity based on B and T lymphocytes, mainly rely on the innate immune system to fight against pathogens (Little, Hultmark & Read, 2005; Milutinovic & Kurtz, 2016). Compared with the phagocytes in vertebrates, invertebrate phagocytes are likely to be of great importance and have even major roles in immune defense (Robb et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Functional characterisation of phagocytes in the Pacific oyster Crassostrea gigas

Jiang

Jia

Zhang

et al. 2016

PeerJ

View full text Add to dashboard Cite

Invertebrates lack canonical adaptive immunity and mainly rely on innate immune system to fight against pathogens. The phagocytes, which could engulf and kill microbial pathogens, are likely to be of great importance and have to undertake significant roles in invertebrate immune defense. In the present study, flow cytometry combined with histological and lectin staining was employed to characterise functional features of phagocytes in the Pacific oyster Crassostrea gigas. Based on the cell size and cellular contents, haemocytes were categorised into three cell types, i.e., granulocytes, semigranulocytes and agranulocytes. Agranulocytes with smaller cell volume and lower cytoplasmic-to-nuclear ratio did not show phagocytic activity, while semigranulocytes and agranulocytes exhibited larger cell volume, higher cytoplasmic-to-nuclear ratio and phagocytic activity. In addition, granulocytes with higher side scatter (SSC) exhibited higher phagocytic activity than that of semigranulocytes. When β-integrin and lectin-like receptors were blocked by RGD tripeptide and carbohydrates, respectively, the phagocytic activity of both granulocytes and semigranulocytes was significantly inhibited, indicating that β-integrin and certain lectin-like receptors were involved in phagocytosis towards microbes. Moreover, lipopolysaccharide but not peptidylglycan could enhance phagocytic activity of granulocytes and semigranulocytes towards Vibrio splendidus and Staphylococcus aureus. Lectin staining analysis revealed that Lycopersicon esculentum lectin (LEL), binding the epitope polylactosamine, was highly distributed on the extracellular cell surface of phagocytes, and could be utilized as a potential molecular marker to differentiate phagocytes from non-phagocytic haemocytes. The results, collectively, provide knowledge on the functional characters of oyster phagocytes, which would contribute to deep investigation of cell typing and cellular immunity in bivalves.

show abstract

Immune Response: Evolution

Baranzini

Engelmann

Grimaldi

2020

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

Innate immune processes arose from specific host–pathogen coevolutive interactions and the ability to recognise self and nonself structures is extremely conserved from invertebrates to vertebrates. In this context, phagocytes represent the most ancient defensive line against foreign materials, already present in earliest protostomes. Moreover, although more complex functions evolved in vertebrates, both cellular and humoral innate immune mechanisms are extremely conserved, leading to identify some forms of innate immune memory also in invertebrates. Key Concepts Phagocytosis represents the first mechanism of defence in metazoans. Immune system has evolved to discriminate self and nonself structures. Immune mechanisms present a high level of conservation throughout phyla . Vertebrate innate immune memory derives from ancient forms and mechanisms already present in invertebrates. Alternative animal models are crucial for investigating the molecular basis of the immune processes.

show abstract

Immune memory in invertebrates

Cited by 232 publications

References 182 publications

Immunity and the coral crisis

Immunity and the coral crisis

Functional characterisation of phagocytes in the Pacific oyster Crassostrea gigas

Immune Response: Evolution

Contact Info

Product

Resources

About