Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed

Tun, Gloria Sz; Gleeson, Dermot; Dube, A; Al-Joudeh, Amer

doi:10.1016/j.jhep.2021.09.031

Cited by 68 publications

(52 citation statements)

References 8 publications

(10 reference statements)

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“…Findings in liver biopsy correlate with reports of AIH following SARS-CoV-2 vaccination. Necroinflammatory hepatitis was observed in all cases of AIH following vaccination with Moderna mRNA-1273 COVID-19 [ [24] , [25] , [26] , [27] , [28] , [29] ], Pfizer-BioNTech mRNA vaccine [ [30] , [31] , [32] , [33] ], and AstraZeneca ChAdOx1 nCoV-19 vaccine [ 8 , 34 ]. It has been suggested that portal infiltration with eosinophils correlates with drug-induced liver injury, including vaccines (i.e., Moderna mRNA-1273 and AstraZeneca ChAdOx1 nCoV-19 vaccines) [ 8 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Necroinflammatory hepatitis was observed in all cases of AIH following vaccination with Moderna mRNA-1273 COVID-19 [ [24] , [25] , [26] , [27] , [28] , [29] ], Pfizer-BioNTech mRNA vaccine [ [30] , [31] , [32] , [33] ], and AstraZeneca ChAdOx1 nCoV-19 vaccine [ 8 , 34 ]. It has been suggested that portal infiltration with eosinophils correlates with drug-induced liver injury, including vaccines (i.e., Moderna mRNA-1273 and AstraZeneca ChAdOx1 nCoV-19 vaccines) [ 8 , 27 , 28 ]. This could partially explain the existence of hepatitis following vaccination without positivity for liver-associated autoantibodies ( Table 1 ) [ 8 , 10 , 12 , 13 , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] ].…”

Section: Discussionmentioning

confidence: 99%

“… McShane et al [ 28 ] Autoimmune hepatitis Moderna mRNA-1273 COVID-19 4 days after 1 dose Bilirubin 270 μmol/L, GOT 217U/L, GPT 1067U/L Positive ASMA antibodies Total IgG 21.77g/L Vuille-Lessard et al [ 26 ] Autoimmune hepatitis Moderna mRNA-1273 COVID-19 2 days after 1 dose Total bilirubin 65 μmol/L, GOT 811 U/L, GPT 579 U/L, ALP 124 U/L, GGT 361 U/L, INR 1.23 Albumin 28 g/L IgG 39.4 g/L Positive ANAs (1:1280), and ASMA Negative Anti-AMA-M2, anti-LKM and anti-LSA antibodies Bril et al [ 31 ] Autoimmune hepatitis Pfizer- BioNTech mRNA vaccine 7 days after 1 dose Bilirubin 4.8 mg/dL, GOT 754 U/L, GPT 2001 U/L ALP 170 U/L Positive ANAs/1:1280- homogeneous pattern) and dsDNA autoantibodies. Negative AMA, ASMA, LKM-1, and ANCAs Total IgG 1081 mg/dL Tun et al [ 27 ] Autoimmune hepatitis Moderna mRNA-1273 COVID-19 3 days after 1 dose Bilirrubin 190 μmol/L, GPT 1048 U/L, GOT 229 U/L Albumin 41 g/L IgG 25.1 g/L, IgM 2.2 g/L, Positive ANAs Garrido et al ...…”

Section: Discussionmentioning

confidence: 99%

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COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Camacho-Domínguez

Rodríguez

Polo

et al. 2022

Journal of Translational Autoimmunity

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Autoimmunity following COVID-19 vaccination has been reported. Herein, a 79-year-old man with clinical and immunological features of autoimmune hepatitis type 1 after ChAdOx1 nCoV-19 vaccination is presented. Clinical manifestations rapidly remitted after the instauration of immunomodulatory management. This case, together with a comprehensive review of the literature, illustrates the association between COVID-19 vaccines and the development of autoimmune conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Camacho-Domínguez

Rodríguez

Polo

et al. 2022

Journal of Translational Autoimmunity

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“…Multiple case reports in the research literature describe liver damage following mRNA vaccines [165][166][167]. A plausible factor leading to these outcomes is the suppression of PPAR-α through downregulation of IRF9, and subsequently decreased sulfatide synthesis in the liver.…”

Section: ππαρ-α συλφατιδε ανδ λι ερ δισεασεmentioning

confidence: 99%

Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs

Seneff

Nigh

Kyriakopoulos³

et al. 2022

Preprint

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The mRNA SARS-CoV-2 vaccines were brought to market in response to the widely perceived public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease had no precedent, but desperate times seemed to call for desperate measures. The mRNA vaccines utilize genetically modified mRNA encoding spike proteins. These alterations hide the mRNA from cellular defenses, promote a longer biological half-life for the proteins, and provoke higher overall spike protein production. However, both experimental and observational evidence reveals a very different immune response to the vaccines compared to the response to infection with SARS-CoV-2. As we will show, the genetic modifications introduced by the vaccine are likely the source of these differential responses. In this paper, we present the evidence that vaccination, unlike natural infection, induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. We explain the mechanism by which immune cells release into the circulation large quantities of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances are shown to have a potentially direct causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, increased tumorigenesis, and DNA damage. We show evidence from adverse event reports in the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines excludes them as positive contributors to public health, even in the context of the Covid-19 pandemic.

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“…Whilst vaccination for the SARS-CoV-2 virus has been successful in reducing the severity and burden of the COVID-19 pandemic, there have been recent reports of mRNA vaccines triggering autoimmune hepatitis in the native liver [ 1 ]. There have been no descriptions thus far of recurrent ‘autoimmune hepatitis’ after liver transplantation in the context of SARS-CoV-2 vaccination.…”

mentioning

confidence: 99%

First report of post-transplant autoimmune hepatitis recurrence following SARS-CoV-2 mRNA vaccination

Mahalingham

Duckworth

Griffiths

2022

Transplant Immunology

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Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed

Cited by 68 publications

References 8 publications

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs

First report of post-transplant autoimmune hepatitis recurrence following SARS-CoV-2 mRNA vaccination

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