Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology

Abstract

Immune-mediated inflammatory diseases (IMIDs) represent a large group of diseases (Crohn’s, ulcerative colitis, psoriasis, lupus, and rheumatoid arthritis) evidenced by systemic inflammation and multiorgan involvement. IMIDs result in a reduced quality of life and an economic burden for individuals, health care systems, and countries. In this brief descriptive review, we will focus on some of the common biological pathways of these diseases from the point of view of psychoneuroimmunoendocrinology (PNIE). PNIE consists of four medical disciplines (psychology, nervous system, immune system, and endocrine system), which are key drivers behind the health–disease concept that a human being functions as a unit. We examine these drivers and emphasize the need for integrative treatments that addresses the disease from a psychosomatic point of view.

Development and validation of a novel biomarker panel for Crohn’s disease and rheumatoid arthritis diagnosis and treatment

“…Recently, both CD and RA have gained recognition as immune-mediated inflammatory conditions that frequently induce systemic inflammation [ 18 , 19 ]. CD and RA are frequently treated with the same medications, implying common underlying pathological processes [ 4 , 20 ].…”

The Role of Mast Cells in the Induction and Maintenance of Inflammation in Selected Skin Diseases

“…In recent years, the answer to the question of how stress affects the development of psoriasis has been sought. Researchers are looking for links between the brain, the peripheral nervous system, the endocrine system, and the immune system [ 71 ].…”

Imunobiologija crijevne suznice: od lokalne imunosti i mikrobioma do zglobne upale

“…ImId i autoimune bolesti predstavljaju teret za oboljelu osobu zbog narušene kvalitete života i mogućeg nastanka invaliditeta, kao i za društvo zbog povećanog i dugotrajnog korištenja zdravstvenih resursa, poglavito u svjetlu činjenice pomaka incidencije prema starijim dobnim skupinama, prvenstveno za ra s prevalencijom u populaciji oko 1%. (48,49) Holobiont kao evolucijska jedinka: interakcija humanog genoma, mikrobioma i okoliša sluznice humanog organizma razlikuju se po svojoj fiziološkoj ulozi, sastavu i broju različitih subpopulacija imunoloških stanica i drugih stanica koje sudjeluju u imunološkoj reakciji sluznice te po uvjetima koji vladaju u određenom (mikro)okolišu. navedene razlike uvjetuju i razlike u sastavu i raznolikosti mikroorganizama koji nastanjuju ekološke niše pojedine sluznice.…”