Immune landscape of vulvar cancer patients treated with surgery and adjuvant radiotherapy revealed restricted T cell functionality and increased IL‐17 expression associated with cancer relapse
Selina Gies,
Patrick Melchior,
Russalina Stroeder
et al.
Abstract:For vulvar cancers, radiotherapy is targeting cancer cells, but also affects the host immune system. As this may affect treatment outcome, in this prospective study, we characterized the individual T cell immune milieu induced by surgery and adjuvant radio +/− chemotherapy (aRT) systemically in the blood of vulvar cancer patients and found increased frequencies of Interleukin (IL)‐17‐producing CD4+ and CD8+ T cells after aRT while frequencies of Th1 and perforin‐producing CD8+ killer cells were strongly dimini… Show more
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