Immune Injury From Organ Preservation

Light, Jimmy A.; Annable, C R; Perloff, Leonard J.; Sulkin, Michael D.; Hill, Gary S.; Etheredge, Edward E.; Spees, Everett K.

doi:10.1097/00007890-197506000-00010

Cited by 19 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He suggested that in patients with red cell cold agglutinins, the kidney allograft should be warmed before establishing a vascular anastomosis. Light et al [4] described histologic and im munofluorescence findings similar to those described herein in plasma-perfused human cadaver kidneys which failed immediately after transplantation. They attributed the fail ure and the finding of IgM and complement in glomeruli and arterial walls to cytotoxic IgM in the plasma perfusate used during pulsatile preservation.…”

Section: Discussionsupporting

confidence: 74%

Cold-Reacting IgM Antibody-Induced Renal Allograft Failure

Sturgill¹,

Lobo

Bolton

1984

Nephron

View full text Add to dashboard Cite

Hyperacute rejection of renal allografts is usually mediated by IgG antibody, but recent studies indicate that cold-reacting IgM alloantibodies are also associated with immediate malfunction of renal allografts. We report 2 cases of cold-reacting IgM-mediated allograft malfunction in which immediate posttransplant biopsies resembled hyperacute rejection. This reaction can probably be prevented by warming the kidney just before transplantation.

show abstract

Section: Discussionsupporting

confidence: 74%

Cold-Reacting IgM Antibody-Induced Renal Allograft Failure

Sturgill¹,

Lobo

Bolton

1984

Nephron

View full text Add to dashboard Cite

show abstract

“…It has been suggested that machine perfusion may pre dispose to early graft rejection [19], The composition of cold perfusate solution used in different centers differed considerably and did not appear to be significant, al though adequate information was not available for anal ysis in every case. Haimov et al [11] postulated that imperfect preservation in their case (air embolism) might have created 'an area of weakness, which, when swelling which usually accompanies acute rejection occurred, be came the starting point of rupture'.…”

Section: Methods Of Preservationmentioning

confidence: 99%

Renal Allograft Rupture: a Report of Three Cases and Review of the Literature

Thukral¹,

Ar²,

Jacobson³

1982

Am J Nephrol

View full text Add to dashboard Cite

This report reviews the features of 149 cases of renal allograft rupture, while adding a detailed description of 3 more cases to the English literature. From November, 1973 to November, 1979, 3 cases of renal allograft rupture occurred in 100 renal transplants performed at Research Medical Center, Kansas City, Mo., an incidence of 3.0%. Rupture developed between the 6th and 8th day after transplantation while patients required dialysis because of poor allograft function. All patients had surgical exploration and successful repair of laceration. Clinical and/or histological findings were consistent with acute rejection in all 3 cases. One graft functioned for 5 years with gradual loss of function. The other two grafts are functioning at the present time. Review of reported cases suggests that acute rejection is the most common cause of allograft rupture. Rupture of the renal allograft did not appear to increase the intensity of rejection, nor did it represent an irreversible rejection. Transplant nephrectomy can be avoided unless hemorrhage is uncontrollable from the site of laceration.

show abstract