Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery

Faraut, Brice; Boudjeltia, Karim Zouaoui; Vanhamme, Luc; Kerkhofs, Myriam

doi:10.1016/j.smrv.2011.05.001

Cited by 345 publications

(258 citation statements)

References 113 publications

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“…These studies have been recently reviewed. 76 The physiologic response to either complete or partial sleep deprivation is to activate components of the infl ammatory system. Most studies have found a nonspecifi c activation of the immune reaction and such as increases in leukocyte and monocyte counts, increases in cytokines such as IL-6 and TNF.…”

Section: Sleep Deprivation and The Immune Systemmentioning

confidence: 99%

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

Parish

2013

Chest

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Section: Sleep Deprivation and The Immune Systemmentioning

confidence: 99%

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

Parish

2013

Chest

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“…Sleep disorders can result in diverse consequences including deleterious effects on immune system, psychiatric diseases and symptoms, or even increased risk of coronary diseases and diabetes mellitus type 2 among others. In this way, sleep disruptions leads to deterioration in the quality of life (Faraut et al 2011;Tsou 2011;Asplund 2000). On the other hand, the consequences of numerous disorders are directly linked to sleep.…”

Section: Introductionmentioning

confidence: 99%

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Bravo

Matito²,

Juánez

et al. 2012

AGE

149

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Melatonin and serotonin rhythms, which exhibit a close association with the endogenous circadian component of sleep, are attenuated with increasing age. This decrease seems to be linked to sleep alterations in the elderly. Chrononutrition is a field of chronobiology that establishes the principle of consuming foodstuffs at times of the day when they are more useful for health, improving, therefore, biorhythms and physical performance. Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay. Data were collected for 3 weeks according to the following schedule: The control week participants consumed standard cereals (22.5 mg tryptophan in 30 g cereals per dose) at breakfast and dinner; for the treatment week, cereals enriched with a higher dose of tryptophan (60 mg tryptophan in 30 g cereals per dose) were eaten at both breakfast and dinner; the posttreatment week volunteers consumed their usual diet. Each participant wore a wrist actimeter that logged activity during the whole experiment. Urine was collected to analyze melatonin and serotonin urinary metabolites and to measure total antioxidant capacity. The consumption of cereals containing the higher dose in tryptophan increased sleep efficiency, actual sleep time, immobile time, and decreased total nocturnal activity, sleep fragmentation index, and sleep latency. Urinary 6-sulfatoxymelatonin, 5-hydroxyindoleacetic acid levels, and urinary total antioxidant capacity also increased respectively after tryptophan-enriched cereal ingestion as well as improving anxiety and depression symptoms. Cereals enriched

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“…Studies have in fact consistently shown that sleep loss, resulting for example from shift-working schedules, is associated with increased risk of accidents and, in the long-term, even health consequences such as type-2 diabetes and cancer [25]. Furthermore, when recurrent sleep loss is not followed by adequate sleep recovery, it can lead to increased risk of infections as well as chronic conditions [26]. In a series of studies, Calogiuri and Weydahl have estimated that participants in long-distance dog sledding competitions sleep, on average, 3–4 hours per day, usually divided into two separate bouts during the day [10,11,19].…”

Section: Resultsmentioning

confidence: 99%

Health challenges in long-distance dog sled racing: A systematic review of literature

Calogiuri

Weydahl

2017

International Journal of Circumpolar Health

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Long-distance dog sled races, e.g. Iditarod (Alaska) and Finnmarksløpet (Northern Norway), are extremely demanding sporting events that might expose mushers, handlers and a large number of organisers and volunteers to risks for their health. The purpose of this systematic literature review (PROSPERO registration n. CRD42017069136) was to identify and summarise all available scientific literature relative to health issues connected to participating in these races. Using a literature search strategy in line with PRISMA guidelines, 117 scientific studies, sought through databases (Google Scholar and PubMed, between 2nd and 9th May 2017) and scrutiny of reference lists, were screened. Studies published in English treating any health issues assessed during or after a long-distance dog sled race were included, with no restriction in relation to their study design or the characteristics of participants studied. The quality of the studies was assessed using a standardised checklist. Ten studies met the criteria for being included in a qualitative analysis. The data synthesis showed that participants underwent strenuous psychophysical load, with insufficient sleep/rest and inadequate energy intake. Findings on hydrations are mixed. The risk of incurring in life-threatening injuries or infections was low, although injuries and infections of minor severity were common. No alterations of blood markers were observed from before to after the races. These findings will help planning prevention and treatment strategies in long-distance dog sled races. However, more research is needed in this field in the future.

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Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery

Cited by 345 publications

References 113 publications

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Health challenges in long-distance dog sled racing: A systematic review of literature

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