Immune hemolytic anemia in a patient with tuberculous lymphadenitis

Tuberculosis (TB) is an airborne illness that induces systemic inflammation. It often affects the lungs causing cough, fever, and chest pain. A commonly associated comorbid condition in TB is anemia. This review article has summarized various studies with an aim to gain a better understanding of pathogenesis and the role of cytokines that contribute to the development of anemia in TB. The study has gathered risk factors that enhance the likelihood of TB patients acquiring anemia. It has reviewed therapeutic modalities such as antitubercular therapy and iron therapy in an attempt to find which of them are effective in reducing the severity of anemia. This review article has also emphasized the importance of measuring hepcidin and ferritin and has touched upon the investigations that can be easily implemented.

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“…Anemia in TB is most often due to nutritional deficiency, malabsorption, and ACD [17]. Low dietary intake is one of the causes resulting in IDA.…”

Section: Review Mechanismmentioning

confidence: 99%

Tuberculosis-Associated Anemia: A Narrative Review

Dasaradhan¹,

Koneti²,

Kalluru³

et al. 2022

Cureus

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“…One-third of cases (34%) were reported from India. They were reported from Mangalore, 2016 [ 19 ], Jaipur, 2015 [ 25 ], Bangalore, 2013 [ 27 ], Nagpur, 2013 [ 29 ], Chennai, 2011 [ 31 ], Varanasi, 2005 [ 35 ] and New Delhi, 2004 [ 36 ]. Considering the highest prevalence of TB infection and the highest reporting of TB induced AIHA cases, it is useful to summarize the clinical and laboratory findings from India.…”

Section: Resultsmentioning

confidence: 99%

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Rathish

Siribaddana

2018

Allergy Asthma Clin Immunol

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BackgroundTuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports.MethodsPubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia. PRISMA statement was used for systematic review. Quality assessment of the selected reports was done using the CARE guidelines.ResultsTwenty-one articles out of 135 search results were included. Thirty-three percent of patients were reported from India. More than half had fever and pallor. The mean haemoglobin was 5.77 g/dl (SD 2.2). Positive direct coombs test was seen in all patients. Pulmonary tuberculosis (43%) was most prevalent. Twenty-nine percent of patients needed a combination of anti-tuberculosis medicines, blood transfusion and steroids. Higher percentage of disseminated TB induced AIHA (67%) needed steroids in comparison to the other types of TB induced AIHA (13%).ConclusionsRarer complications of tuberculosis such as auto-immune haemolytic anaemia should be looked for especially in disease-endemic areas. Blood transfusion and steroids are additional treatment options along with the anti-tuberculosis medicines.Electronic supplementary materialThe online version of this article (10.1186/s13223-018-0236-y) contains supplementary material, which is available to authorized users.

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“…This confirmed the absence of normochromic normocytic anemia of chronic disease that is associated with TB. 7 Anti-tuberculosis therapy (ATT) with isoniazid, rifampicin, pyrazinamide and ethambutol was started. As per World Health Organization (WHO) TB treatment guidelines, Category 1 ATT regimen for CTB was given which included 2 months intensive phase and 4 months continuation phase.…”

Section: Case Presentationmentioning

confidence: 99%

Tuberculosis Verucossa Cutis of Hand: A Case Report

Prathyusha¹,

Sainudheen²,

Puthean³

2021

Nepal J Dermatol Venereol & Leprol

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Tuberculosis verrucosa cutis (TBVC) is exogenous paucibacillary cutaneous tuberculosis (CTB) and is the third commonest type of CTB. Clinically, TBVC usually begins as isolated or multiple warty papules, and soon acquires a verrucous plaque and are usually located in the extremities. Here we report a case of 41-year-old South Indian woman presenting with occasional pruritus, erythematous scaly nodules and warty plaques on the back of right hand following nail prick. A positive Mantoux test, skin biopsy showing granuloma and related epidemiologic, clinical and histopathologic data with an excellent response of patient to the treatment confirmed TBVC.

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Immune hemolytic anemia in a patient with tuberculous lymphadenitis

Cited by 15 publications

References 7 publications

Tuberculosis-Associated Anemia: A Narrative Review

Tuberculosis-Associated Anemia: A Narrative Review

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Tuberculosis Verucossa Cutis of Hand: A Case Report

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