Immune Globulins

Characterization of source plasma from self‐identified vaccinated or convalescent donors during the 2009 H1N1 pandemic

“…Passive immunization with polyclonal antibodies that target specific pathogens is a well‐known and effective method of achieving protection against a variety of diseases in humans . Specific anti‐influenza neutralizing antibodies can be delivered by transfusion of plasma from convalescent donors or donors vaccinated against the strain of interest .…”

Immunoglobulin G3 from Polyclonal Human Immunodeficiency Virus (HIV) Immune Globulin Is More Potent than Other Subclasses in Neutralizing HIV Type 1

“…Passive immune globulin therapy has been successfully used to prevent infection with a variety of viruses, including varicella-zoster virus, measles virus, hepatitis A virus, hepatitis B virus, cytomegalovirus, respiratory syncytial virus, and rabies virus (14,15,31,43). Primate studies in vivo have suggested that human immunodeficiency virus (HIV) infection might be preventable by anti-HIV antibodies (1,2,4,20,36).…”

Immune globulin potency: challenges and opportunities

“…Polio IG, despite early promise, was not clearly effective for prevention of poliovirus during outbreaks . Finlayson wrote in 1979 that “antibodies to diphtheria and polio are measured [in IGs] in order to control manufacturing consistency,” and this remains the case. The striking success of worldwide poliovirus vaccination has brought poliovirus to the threshold of eradication.…”

“…The striking success of worldwide poliovirus vaccination has brought poliovirus to the threshold of eradication. As discussed by Oberste, wild‐type poliovirus type 2 is officially eradicated and types 1 and 3 are soon to follow . The World Health Organization has initiated a Global Action Plan to prevent accidental dissemination of polioviruses, by setting forth requirements for laboratories and vaccine manufacturers who need to culture poliovirus .…”