Immune gene polymorphisms associated with poor response to platelet transfusion and recombinant factor VII administration in Glanzmann thrombasthenia
Majid Naderi,
Ilia Mirzaei,
Omid Seidizadeh
et al.
Abstract:IntroductionPoor response to platelet and recombinant factor VII administration is a major problem in patients with Glanzmann Thrombasthenia (GT). The risk factors associated with poor response to treatment in these patients are unknown. Some genetic variations of cytokines may contribute to therapy resistance.AimsWe evaluated, for the first time, whether genetic polymorphisms on cytokine genes are related to poor treatment response in GT patients.MethodsWe enrolled 30 patients with GT (15 resistant and 15 non… Show more
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