Immune Factors in Narcolepsy

Langdon, Nicola; Lock, Christopher; Welsh, K; Vergani, Diego; Dorow, R.; Wachtel, H.; Palenschat, D; Parkes, J. D.

doi:10.1093/sleep/9.1.143

Cited by 53 publications

(12 citation statements)

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“…Again, Fisher's exact tests did not indicate a significant difference. Age of the OCB-positive narcoleptic patients (18.5, 23.9, 29.8, and 65.5 years) and disease duration (8,10,12, and 30 years, respectively) were in the range of the entire group of narcoleptic patients. See table 1 for more detailed information about the OCB-positive patients.…”

Section: Resultsmentioning

confidence: 91%

Oligoclonal Bands and Specific Antibody Indices in Human Narcolepsy. Oligoklonale Banden und spezifische Antikorper Indizes bei Patienten mit Narkolepsie

2004

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Question of the study Recent studies suggest that an acquired orexin deficiency plays a crucial role in the pathophysiology of human narcolepsy. Because the disease is strongly associated with the HLA-DR2 or DQB1*0602 antigen in the Caucasian population it has been hypothesized that autoimmune processes may target and destroy orexin-producing neurons. Patients and methods To identify signs of chronic inflammation or previous CNS infection, we investigated serum and cerebrospinal fluid (CSF) from a group of 22 narcoleptic patients and a control group of 22 patients suffering from major depression and looked for the occurrence of oligoclonal bands and significantly elevated specific antibody indices for important neurotropic viruses and Toxoplasma. Results Oligoclonal bands were present in 4 out of 22 narcoleptic patients compared to 1 out of 22 patients from the control group. In three of these four narcoleptic patients, specific antibody indices were present against herpes simplex or cytomegalovirus, respectively. Although the incidence of pathological CSF findings was higher in narcoleptic patients compared to the control group, statistical analysis did not reveal a significant difference between the two groups. Conclusions On the basis of the present results, no convincing evidence of chronic inflammation or previous infection supporting an autoimmune pathophysiology for narcolepsy could be identified.

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Section: Resultsmentioning

confidence: 91%

Oligoclonal Bands and Specific Antibody Indices in Human Narcolepsy. Oligoklonale Banden und spezifische Antikorper Indizes bei Patienten mit Narkolepsie

2004

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“…cataleptic attacks, and two or more SOREMPs) but were negative for DR2 when serotyped [Langdon et al, 1986;Andreas-Zeitz et al, 1986;Guilleminault and Grumet, 1986;Mitler et al, 1986;Neely et al, 19861. Hence, it is no longer feasible to consider narcolepsy a disease with 100% DR2 association.…”

Section: Discussionmentioning

confidence: 99%

HLA‐DR restriction‐fragment‐length polymorphisms in narcolepsy

Holloman

Bell

Kilduff

et al. 1987

J of Neuroscience Research

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Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragment-length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compared with a homozygous DR2-Dw2 cell line failed to reveal any polymorphism when digested with six restriction endonucleases and hybridized with three different cDNA probes. None of the three patients with central nervous system hypersomnia, a syndrome similar to narcolepsy, were DR2-positive. We conclude that any polymorphism of the DR beta, DQ alpha, or DQ beta genes of DR2 narcoleptics that might distinguish them from DR2 normals cannot be resolved through RFLP analysis.

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“…Across various ethnic groups, > 85% of all narcoleptic patients with definite cataplexy share a specific HLA allele, HLA DQB1*0602 (most often in combination with HLA DR2), compared with 12%-38% of the general population (Mignot 1998). Such close association with the HLA system has led to the suggestion that narcolepsy may be an autoimmune disease (Langdon et al 1986). …”

Section: Narcolepsy In Humansmentioning

confidence: 99%

Sleepy Dogs Don't Lie: A Genetic Disorder Informative About Sleep: Figure 1.

Kilduff¹

2001

Genome Res.

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Immune Factors in Narcolepsy

Cited by 53 publications

References 0 publications

Oligoclonal Bands and Specific Antibody Indices in Human Narcolepsy. Oligoklonale Banden und spezifische Antikorper Indizes bei Patienten mit Narkolepsie

Oligoclonal Bands and Specific Antibody Indices in Human Narcolepsy. Oligoklonale Banden und spezifische Antikorper Indizes bei Patienten mit Narkolepsie

HLA‐DR restriction‐fragment‐length polymorphisms in narcolepsy

Sleepy Dogs Don't Lie: A Genetic Disorder Informative About Sleep: Figure 1.

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