Immune Exophthalmos Due to Harderian Gland Antigen

Pisarev, Mario A.; Altschuler, N; Davison, Tomás A.

doi:10.1210/endo-83-4-903

Cited by 17 publications

(1 citation statement)

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“…Moreover, Dandona & El Kabir (1970) showed an effect of exophthalmic sera on the weight of guinea-pig Harderian gland, and Fakhri & Hobbs ( 1972) demonstrated antibodies which cooperated with normal lymphocytes in the sera of some patients with ophthalmopathy. Antibodies against guinea-pig Harderian gland extract have been detected using a hemagglutination test (Pisarev et al, 1968). The work showing that TSH subfragments together with an 'abnormal immunoglobulin' bind to eye muscle membranes (Kohn & Winand, 1971;1972;Winand & Kohn, 1975) needs to be confirmed, particularly as this has been proposed by these workers as the mechanism for Graves' ophthalmopathy.…”

Section: Discussionmentioning

confidence: 95%

Failure of Haemagglutination and Immunofluorescence Methods to Detect Serum Orbital Antibodies in Patients With Graves' Ophthalmopathy

Henderson

Wall

1981

Clinical Endocrinology

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Serum antibodies against human, bovine, and guinea-pig, orbital antigens were tested for in patients with Graves' ophthalmopathy using haemagglutination and immunofluorescence techniques. Although low titres of antibodies were demonstrated in a small proportion of patients with Graves' ophthalmopathy, the prevalence was similar to that for normal subjects using both tests. The significance of these findings and the evidence for a role of autoantibodies in the pathogenesis of Graves' ophthalmopathy are discussed.

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Section: Discussionmentioning

confidence: 95%