Immune Evasion by<i>Staphylococcus aureus</i>

Jong, Nienke W.M. de; Kessel, Kok P. M. van; Strijp, Jos A. G. van

doi:10.1128/9781683670131.ch39

Cited by 27 publications

(41 citation statements)

References 221 publications

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“…Humans harboring defects in neutrophil and T cell function and IL-17 signaling present with recurrent infection (11), an observation corroborated by mouse models that demonstrate the importance of innate and adaptive immunity (12)(13)(14)(15)(16). S. aureus thwarts immunity through an array of virulence factors (17) including α-toxin (Hla), a pore-forming cytotoxin that contributes to superficial and invasive disease (18)(19)(20) and perturbs host immunity during skin infection (21) and recurrent disease (22). Commensurate with this observation, the anti-Hla antibody response is a correlate of protection against recurrent skin infection (7) and bacteremia (23).…”

Section: Introductionmentioning

confidence: 88%

Staphylococcus aureus toxin suppresses antigen-specific T cell responses

Lee¹,

Olaniyi²,

Kwieciński³

et al. 2020

Journal of Clinical Investigation

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Section: Introductionmentioning

confidence: 88%

Staphylococcus aureus toxin suppresses antigen-specific T cell responses

Lee¹,

Olaniyi²,

Kwieciński³

et al. 2020

Journal of Clinical Investigation

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“…There was no visible change on the E. coli cell surface as exhibited by confocal images ( Supplementary Figure S1 ). S. aureus proteins bind to the Fc region of IgG molecules and manipulate the host immune response ( Atkins et al, 2008 ; Thammavongsa et al, 2015 ; De Jong et al, 2019 ). Further, S. aureus Fc binding property was visualized using confocal microscopy.…”

Section: Resultsmentioning

confidence: 99%

Sortase A Mediated Bioconjugation of Common Epitopes Decreases Biofilm Formation in Staphylococcus aureus

et al. 2020

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Staphylococcus aureus is one of the most notorious pathogens and is frequently associated with nosocomial infections imposing serious risk to immune-compromised patients. This is in part due to its ability to colonize at the surface of indwelling medical devices and biofilm formation. Combating the biofilm formation with antibiotics has its own challenges like higher values of minimum inhibitory concentrations. Here, we describe a new approach to target biofilm formation by Gram positive bacteria. Sortase A is a transpeptidase enzyme which is responsible for tagging of around ∼22 cell surface proteins onto the outer surface. These proteins play a major role in the bacterial virulence. Sortase A recognizes its substrate through LPXTG motif. Here, we use this approach to install the synthetic peptide substrates on S. aureus. Sortase A substrate mimic, 6His-LPETG peptide was synthesized using solid phase peptide chemistry. Incorporation of the peptide on the cell surface was measured using ELISA. Effect of peptide incubation on Staphylococcus aureus biofilm was also studied. 71.1% biofilm inhibition was observed with 100 µM peptide while on silicon coated rubber latex catheter, 45.82% inhibition was observed. The present work demonstrates the inability of surface modified S. aureus to establish biofilm formation thereby presenting a novel method for attenuating its virulence.

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“…This pathogen is also able to withstand phagocyte-mediated killing. Though most studies on S. aureus /phagocyte interactions focused on neutrophils (de Jong et al, 2019 ), macrophages also gained attention as they may be “Trojan horses” used by bacteria to disseminate throughout the body. Accordingly, S. aureus can resist phagocytic oxidative and nitrosative killing, antimicrobial peptides and nutritional immunity (Flannagan et al, 2015 ).…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria

Leseigneur

Lê-Bury

Pizarro‐Cerdá

et al. 2020

Front. Cell. Infect. Microbiol.

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Macrophages participate to the first line of defense against infectious agents. Microbial pathogens evolved sophisticated mechanisms to escape macrophage killing. Here, we review recent discoveries and emerging concepts on bacterial molecular strategies to subvert macrophage immune responses. We focus on the expanding number of fascinating subversive tools developed by Listeria monocytogenes, Staphylococcus aureus, and pathogenic Yersinia spp., illustrating diversity and commonality in mechanisms used by microorganisms with different pathogenic lifestyles.

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Immune Evasion byStaphylococcus aureus

Cited by 27 publications

References 221 publications

Staphylococcus aureus toxin suppresses antigen-specific T cell responses

Staphylococcus aureus toxin suppresses antigen-specific T cell responses

Sortase A Mediated Bioconjugation of Common Epitopes Decreases Biofilm Formation in Staphylococcus aureus

Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria

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