2022
DOI: 10.3389/fimmu.2022.937684
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Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus

Abstract: Severe fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), poses a serious threat to global public health, with high fatalities and an increasing prevalence. As effective therapies and prevention strategies are limited, there is an urgent need to elucidate the pathogenesis of SFTS. SFTSV has evolved several mechanisms to escape from host immunity. In this review, we summarize the mechanisms through which SFTSV escapes host immune responses, including the inhibition of innate imm… Show more

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Cited by 7 publications
(7 citation statements)
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References 80 publications
(129 reference statements)
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“…Adaptive immune response and transcription in #7 protein. Wang et al ( 46 ) summarized the mechanism of SFTSV evasion of the host immune response and highlighted that SFTSV can escape from host immune responses via multiple strategies, such as interfering with the number and function of innate and adaptive immune cells, inhibiting the inhibiting interferon signaling pathway, regulating the NF-κB signaling, and autophagy. Moreover, a proposed strategy against the virus may be to regulate the host dysfunctional immune cells.…”
Section: Discussionmentioning
confidence: 99%
“…Adaptive immune response and transcription in #7 protein. Wang et al ( 46 ) summarized the mechanism of SFTSV evasion of the host immune response and highlighted that SFTSV can escape from host immune responses via multiple strategies, such as interfering with the number and function of innate and adaptive immune cells, inhibiting the inhibiting interferon signaling pathway, regulating the NF-κB signaling, and autophagy. Moreover, a proposed strategy against the virus may be to regulate the host dysfunctional immune cells.…”
Section: Discussionmentioning
confidence: 99%
“…Occasionally, PRRs may act not as an "adversary" but an "accomplice" for pathogens. In mammals, viruses promote invasion by binding to pattern recognition receptors and escape from the innate immune response by interfering with signal transduction and cellular immunity (178). Immune escape by pathogens may lead to persistent infection and even cancer.…”
Section: Immune Escapementioning
confidence: 99%
“…Immune escape is referred to the biological behavior of tumor that can be further accelerated after it is removed from the body's immune monitoring, thus promoting the proliferation, invasion, and metastasis of tumor 21 . To explore the immune escape mechanism of tumor is crucial adjective for the treatment of tumor, especially immunotherapy.…”
Section: Introductionmentioning
confidence: 99%
“…Immune escape is referred to the biological behavior of tumor that can be further accelerated after it is removed from the body's immune monitoring, thus promoting the proliferation, invasion, and metastasis of tumor. 21 To explore the immune escape mechanism of tumor is crucial adjective for the treatment of tumor, especially immunotherapy. One research uncovered that circ_0000877 regulated diffuse large B-cell lymphoma (DLBCL) tumor progression and immune escape by regulating miR-370-3p/mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)/Hippo pathways.…”
mentioning
confidence: 99%