Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan

Xin, Yingji; Ji, Hyanggi; Cho, Eunae; Roh, Kyung‐Baeg; You, Ji Young; Park, Deokhoon; Jung, Eunsun

doi:10.1016/j.bbrep.2022.101256

Cited by 15 publications

(17 citation statements)

References 33 publications

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“…Plant-derived β-glucan, from plants such as oats, is insoluble in water. Therefore to overcome this, a solubulizer and glycerin are added in the medicinal and cosmetic industry (59). Glycerin, as a natural moisturizer, has long been known for its topical benefits.…”

Section: Discussionmentioning

confidence: 99%

Application of a Synbio-Glucan Functional Spray for Canine Atopic Dermatitis

Kim

Jeong

et al. 2023

J Vet Clin

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Atopic dermatitis (AD) is a common skin disease in animals and several therapeutic trials with various drugs have been conducted for more effective management of AD. However, these trials have not been able to properly address all the aspects of AD management because of the lack of good efficacy or due to significant side effects of the drugs being tested. Synbio-glucan functional spray is a functional skin spray using Synbio-glucan composed of β-glucan and probiotics. We designed a functional spray composed of Synbio-glucan (patent application number:10-1805863), distilled water, glycerin, solubilizer, and 40% alcohol. We tested the efficacy and safety of the functional spray on six dogs with AD. The trial was conducted with the consent of the caregivers. The spray was applied to the skin lesions, including the trunk, axillae, inguinal region, or periocular areas, thrice a day for 30 days. To evaluate the efficacy of this functional spray, we assessed the pruritus visual analog scale (PVAS) and the canine atopic dermatitis extent and severity index (CADESI)-4. At the end of one month, the results clinical scores after functional spray treatment showed a significant decrease in the PVAS (p = 0.03) and CADESI-4 (p = 0.03) in all the subject dogs with AD. This study thus confirmed that the Synbio-glucan functional spray is efficacious and safe for the treatment of AD in dogs.

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Section: Discussionmentioning

confidence: 99%

Application of a Synbio-Glucan Functional Spray for Canine Atopic Dermatitis

Kim

Jeong

et al. 2023

J Vet Clin

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“…Soluble β-glucans can increase intestinal transit time which includes the gelforming β-glucans (Bashir & Choi, 2017). Soluble beta-glucan was produced through enzymatic hydrolysis (Xin et al, 2022). Insoluble beta-glucan can be found in yeast cell wall can be utilized as functional food based on its excellent immuneenhancing effect (Samuelsen et al, 2014).…”

Section: Definition and Different Preparation Ofmentioning

confidence: 99%

“…Insoluble beta-glucan can be found in yeast cell wall can be utilized as functional food based on its excellent immuneenhancing effect (Samuelsen et al, 2014). The use of yeast cell wall-glucan has been limited because it is not soluble in water (Xin et al, 2022).…”

Section: Definition and Different Preparation Ofmentioning

confidence: 99%

The Potential of beta-glucan as feed additives in broiler chickens: A review

Purnamasari

Cruz²,

Cruz³

2022

J. Ilmu Peternak. Terap.

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Poultry as an industry was continuously growing worldwide and demands for poultry meats were markedly increasing. However, the limited use of antibiotics as treatments and as growth promoters became a serious problem due to the emergence of antibiotic resistance. Therefore, exploring other alternatives such as using feed additives like beta-glucans were widely studied and used to meet the demands of the consumers. This review focused on the different functions and effects of beta-glucans in poultry. Beta-glucans were known to have immunomodulation effects by upregulating the cytokines and other immune cells to overcome a disease. Aside from its immunomodulation effects, it can also increase the intestinal villi and crypts. Furthermore, an increase in growth performance was also observed. This evidence is promising but further research is required to properly establish the various functions of beta-glucans in poultry.

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“…42,43 Plethora of studies have shown that β-glucan was an effective aquafeed additive, used to improve the immune function, growth, lysozyme activity and antiinfection ability of aquatic animals. [44][45][46][47][48][49][50][51] Ebrahimi et al 52 reported that feeding of common carp (Cyprinus carpio) with an immunostimulant prepared from Mannanoligosaccharides and β-glucan resulted in a significant increase in the number of leucocytes and improve resistance against A. hydrophila. 52 Modulation of the diet of red sea bream (Pagrus major) with 0.025% heat killed L. plantarum combined with 0.1% β-glucan enhanced the activities of alternative complement pathway and peroxidase.…”

Section: Introductionmentioning

confidence: 99%

Immune disorders induced by improper use of dietary immunostimulants in aquatic animals: Research progress and prospective solutions by targeting gut microbiota

Zhang,

Yang,

Teame

et al. 2023

Reviews in Aquaculture

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Immunostimulants were widely used in aquafeed due to their multiple important functions, including promoting growth, enhancing non‐specific defence mechanisms and resisting infectious diseases. But the efficiencies of the positive effects of immunostimulants were affected by the duration of the administration and their dose. Short‐term and normal‐dose of immunostimulants promoted the growth and enhance non‐specific immunity of aquatic animals. However, improper use led to several immune disorders, including immune tolerance, immune exhaustion and over‐immunity. The application of two immunostimulant diets in rotation technique and the intermittent use of immune stimulant diets may solve the problems associated with immune disorders, but this application method will be limited by both species and immunostimulants. The occurrence of immune disorders is accompanied by different degrees of gut microbiota dysbiosis, especially significantly up‐regulated the abundance of Proteobacteria. Besides, the gut symbiotic microbiota plays a significant role in host immunity. Consequently, the regulation of gut microbiota may be an effective way to modulate immune disorders caused by improper use of polysaccharide immunostimulants. Regulating the gut microbiota not only solves the negative effects caused by improper use of immunostimulants without restrictions on both species and immunostimulants, but also has the advantage of simplicity and convenience compared to conventional approaches. In summary, this article reviews the possible negative effects caused by improper use of immunostimulants on aquatic animals and compares regular approaches with regulating gut microbiota. And gut microbiota maybe be used as a therapeutic target to improve immune disorders caused by immunostimulants in aquatic animals.

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Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan

Cited by 15 publications

References 33 publications

Application of a Synbio-Glucan Functional Spray for Canine Atopic Dermatitis

Application of a Synbio-Glucan Functional Spray for Canine Atopic Dermatitis

The Potential of beta-glucan as feed additives in broiler chickens: A review

Immune disorders induced by improper use of dietary immunostimulants in aquatic animals: Research progress and prospective solutions by targeting gut microbiota

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