Immune-Enhancing Activity of Compound Polysaccharide on the Inactivated Influenza Vaccine

Zhang, Yang; Wang, Depeng; Yu, Yang; Lin, Xinhua; Liang, Ming; YiXin, Yu; Sun, Lishan; Tan, Daotong; He, Xiaoxi; Yu, Guangli; Wang, Wei; Cai, Chenxi

doi:10.2139/ssrn.4229478

Cited by 2 publications

(3 citation statements)

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“…To investigate the relationship between NH 3 oxidation activity and the surface structure of Pt/CeO 2 and Pt/CxZy catalysts, the results from catalytic performance evaluation and different characterizations were reorganized and illustrated in Figure 8. As discussed in the sections of AC- Based on XPS results and our previous study, 27 it was further proposed that the generation of more surface defects and Ce 3+ by the addition of 10% ZrO 2 into CeO 2 could benefit the reaction between PtO 2 and Ce 3+ , thus producing higher CN Pt−O−Ce and stronger Pt-CeO 2 interaction. However, with more ZrO 2 doping, although a relatively higher concentration of surface defects and Ce 3+ could be achieved on C7Z3 and C5Z5, weaker Pt-CeO 2 interaction was actually observed on Pt/C7Z3 and Pt/C5Z5 catalysts.…”

Section: Surface Adsorption Properties and Reaction Mechanismmentioning

confidence: 82%

Tuning the Interaction between Platinum Single Atoms and Ceria by Zirconia Doping for Efficient Catalytic Ammonia Oxidation

Tan,

Cai,

et al. 2023

Environ. Sci. Technol.

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Aiming at the development of an efficient NH 3 oxidation catalyst to eliminate the harmful NH 3 slip from the stationary flue gas denitrification system and diesel exhaust aftertreatment system, a facile ZrO 2 doping strategy was proposed to construct Pt 1 /Ce x Zr 1−x O 2 catalysts with a tunable Pt-CeO 2 interaction strength and Pt−O−Ce coordination environment. According to the results of systematic characterizations, Pt species supported on Ce x Zr 1−x O 2 were mainly in the form of single atoms when x ≥ 0.7, and the strength of the Pt-CeO 2 interaction and the coordination number of Pt−O−Ce bond (CN Pt−O−Ce ) on Pt 1 /Ce x Zr 1−x O 2 showed a volcanic change as a function of the ZrO 2 doping amount. It was proposed that the balance between the reasonable concentration of oxygen defects and limited surface Zr−O x species well accounted for the strongest Pt-CeO 2 interaction and the highest CN Pt−O−Ce on Pt/Ce 0.9 Zr 0.1 O 2 . It was observed that the Pt/Ce 0.9 Zr 0.1 O 2 catalyst exhibited much higher NH 3 oxidation activity than other Pt/Ce x Zr 1−x O 2 catalysts. The mechanism study revealed that the Pt 1 species with the stronger Pt-CeO 2 interaction and higher CN Pt−O−Ce within Pt/Ce 0.9 Zr 0.1 O 2 could better activate NH 3 adsorbed on Lewis acid sites to react with O 2 thus resulting in superior NH 3 oxidation activity. This work provides a new approach for designing highly efficient Pt/CeO 2 based catalysts for low-temperature NH 3 oxidation.

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Section: Surface Adsorption Properties and Reaction Mechanismmentioning

confidence: 82%

Tuning the Interaction between Platinum Single Atoms and Ceria by Zirconia Doping for Efficient Catalytic Ammonia Oxidation

Tan,

Cai,

et al. 2023

Environ. Sci. Technol.

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“…18,19 Despite viral infection, cGAS stimulation can also be triggered by host DNA. 14,20,21 Theoretically, autoimmunity might result from the cGAS abnormally detecting self-DNA, according to the original definition of intracellular DNA sensing. [22][23][24] Numerous varieties of DNA damage, both exogenous and endogenous, are possible sources of these DNAs.…”

Section: The C G a S-s Ting-irfa Xismentioning

confidence: 99%

“…Despite viral infection, cGAS stimulation can also be triggered by host DNA 14,20,21 . Theoretically, autoimmunity might result from the cGAS abnormally detecting self‐DNA, according to the original definition of intracellular DNA sensing 22–24 .…”

Section: The Cgas–sting–irf3 Axismentioning

confidence: 99%

Harnessing cGAS–STING axis for therapeutic benefits in systemic lupus erythematosus

Chang

2024

Int J of Rheum Dis

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The cyclic GMP–AMP synthase (cGAS), a prominent intracellular DNA sensor in mammalian cells, controls the innate immune response and the stimulator of interferon genes (STING)‐mediated synthesis of pro‐inflammatory cytokines, such as type‐I interferon (IFN‐I). For decades, IFN‐I has been hypothesized to be essential in the development of systemic lupus erythematosus (SLE), a chronic multisystem autoimmunity characterized by immune complex (IC) deposition in small vessels. Recent findings revealed that the activation of the cGAS–STING pathway by self‐DNA would propagate the autoimmune responses via upregulating IFN‐I production in SLE. In this review, we aimed to provide a comprehensive outlook of the role of the cGAS–STING pathway in SLE pathobiology, as well as, a better understanding of current therapeutic opportunities targeting this axis.

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Immune-Enhancing Activity of Compound Polysaccharide on the Inactivated Influenza Vaccine

Cited by 2 publications

References 0 publications

Tuning the Interaction between Platinum Single Atoms and Ceria by Zirconia Doping for Efficient Catalytic Ammonia Oxidation

Tuning the Interaction between Platinum Single Atoms and Ceria by Zirconia Doping for Efficient Catalytic Ammonia Oxidation

Harnessing cGAS–STING axis for therapeutic benefits in systemic lupus erythematosus

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