Immune Enhancement of Clam Peptides on Immunosuppressed Mice Induced by Hydrocortisone

Abstract

Clam peptides, marine-derived biological peptides, have been broadly investigated and applied as health foods, among which immunomodulation is one of their biological activities that cannot be ignored in vivo. In this study, we concentrated on exploring the effects of Ruditapes philippinarum peptides (RPPs) on immunomodulation and the balance of intestinal microbiota in hydrocortisone (HC)-induced immunosuppressed mice. The results revealed that RPPs could increase the thymus and spleen indices and number of white blood cells, promote the secretion level of cytokines (IL-2, IL-6, TNF-α, and INF-γ), repair the morphology of the spleen and thymus, and enhance the proliferation of T-lymphocyte subsets in immunosuppressed mice. Moreover, RPPs improved the abundance of beneficial bacteria and preserved the ecological equilibrium of the gut microbiota. In conclusion, RPPs have significant immunomodulatory effects on immunosuppressed mice and may be developed as immunomodulators or immune adjuvants in functional foods and drugs; they are also beneficial to the utilization of the high value of marine shellfish.

Anti-Inflammatory Activity of Peptides from Ruditapes philippinarum in Lipopolysaccharide-Induced RAW264.7 Cells and Mice

“…In Oriental folk medicine, Ruditapes philippinarum is a marine treasure for preventing illnesses in humans (chronic bronchitis, dry cough, phlegm, etc.) [ 21 ]. Ruditapes philippinarum has been proven to have antioxidant [ 22 , 23 ], antitumor [ 24 ], hepatoprotective [ 25 ], hypoglycemic [ 26 , 27 ], hypotensive [ 22 ], antimicrobial [ 28 ], anticarcinogenic [ 29 ], immunomodulatory [ 21 ], and other effects, but there are few studies on its anti-inflammatory activity.…”

“…[21]. Ruditapes philippinarum has been proven to have antioxidant [22,23], antitumor [24], hepatoprotective [25], hypoglycemic [26,27], hypotensive [22], antimicrobial [28], anticarcinogenic [29], immunomodulatory [21], and other effects, but there are few studies on its anti-inflammatory activity.…”